PMBL_genes - morinlab/LLMPP GitHub Wiki

title: 'PMBL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of PMBL genes

Tier 1 PMBL genes

76 total

Gene Tier First PMBL evidence Other entities
ACTB 1 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] [@lohrDiscoveryPrioritizationSomatic2012a]
ARID1A 1 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] [@rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b]
ARID5B 1 Gomez et al[@gomezUltraDeepSequencingReveals2023] [@reddyGeneticFunctionalDrivers2017]
B2M 1 Reichel et al[@reichelFlowSortingExome2015a] [@pararajalingamCodingNoncodingDrivers2020; @morinFrequentMutationHistonemodifying2011]
BIRC6 1 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@reddyGeneticFunctionalDrivers2017]
BTG1 1 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]
CD58 1 Schneider et al[@schneiderAlterationsCD58Gene2015a] [@morinFrequentMutationHistonemodifying2011]
CD83 1 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @morinMutationalStructuralAnalysis2013]
CDKN2A 1 [@spinaGeneticsNodalMarginal2016b; @morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]
CHD8 1 [@grandeGenomewideDiscoverySomatic2019]
CIITA 1 Mottok et al[@mottokGenomicAlterationsCIITA2015b] [@morinFrequentMutationHistonemodifying2011]
CISH 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
CREBBP 1 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @loveGeneticLandscapeMutations2012]
CSF2RB 1 Reichel et al[@reichelFlowSortingExome2015a]
DDX3X 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@schmitzBurkittLymphomaPathogenesis2012; @reddyGeneticFunctionalDrivers2017]
DTX1 1 Gomez et al[@gomezUltraDeepSequencingReveals2023] [@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]
DUSP2 1 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@lohrDiscoveryPrioritizationSomatic2012a]
EBF1 1 Reichel et al[@reichelFlowSortingExome2015a] [@thomasGeneticSubgroupsInform2023; @bohleRoleEarlyBcell2013]
EEF1A1 1 Reichel et al[@reichelFlowSortingExome2015a] [@hubschmannMutationalMechanismsShaping2021b]
ETS1 1 [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]
EWSR1 1 [@pararajalingamCodingNoncodingDrivers2020]
EZH2 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@morinSomaticMutationsAltering2010a; @loveGeneticLandscapeMutations2012]
FAS 1 [@spinaGeneticsNodalMarginal2016b; @schollMutationsRegionFAS2007]
FAT1 1 [@spinaGeneticsNodalMarginal2016b]
FAT4 1 [@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013]
GNA13 1 Reichel et al[@reichelFlowSortingExome2015a] [@morinFrequentMutationHistonemodifying2011; @loveGeneticLandscapeMutations2012]
HIST1H1B 1 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@chapuyMolecularSubtypesDiffuse2018b; @krysiakRecurrentSomaticMutations2017b]
HIST1H1C 1 [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]
HIST1H1D 1 [@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b]
HIST1H1E 1 Reichel et al[@reichelFlowSortingExome2015a] [@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a]
HLA-B 1 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] [@lohrDiscoveryPrioritizationSomatic2012a]
IL4R 1 Vigano et al[@viganoSomaticIL4RMutations2018b] [@dunsCharacterizationDLBCLPMBL2021b]
IRF8 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
ITPKB 1 Reichel et al[@reichelFlowSortingExome2015a] [@schmitzGeneticsPathogenesisDiffuse2018a]
JAK1 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@zhangGeneticHeterogeneityDiffuse2013]
KMT2C 1 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019; @zhangGeneticHeterogeneityDiffuse2013]
LTB 1 Desch et al[@deschGenotypingCirculatingTumor2020] [@chapuyMolecularSubtypesDiffuse2018b]
MAP3K14 1 Otto et al[@ottoGeneticLesionsTRAF32012a] [@rossiAlterationBIRC3Multiple2011a]
MS4A1 1 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@rushtonGeneticEvolutionaryPatterns2020]
NFKBIA 1 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] [@lakeMutationsNFKBIAEncoding2009; @russler-germainMutationsAssociatedProgression2023b]
NFKBIE 1 Mansouri et al[@mansouriFrequentNFKBIEDeletions2016] [@morinGeneticLandscapesRelapsed2016; @pararajalingamCodingNoncodingDrivers2020]
OSBPL10 1 [@zhangGeneticHeterogeneityDiffuse2013]
P2RY8 1 [@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]
PCLO 1 [@lohrDiscoveryPrioritizationSomatic2012a]
PHIP 1
PIM1 1 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
PIM2 1 Reichel et al[@reichelFlowSortingExome2015a] [@arthurGenomewideDiscoverySomatic2018]
PRKDC 1 [@hubschmannMutationalMechanismsShaping2021b; @schmitzGeneticsPathogenesisDiffuse2018a]
PTPN1 1 Gunawardana et al[@gunawardanaRecurrentSomaticMutations2014c]
PTPRD 1 [@spinaGeneticsNodalMarginal2016b]
RHOA 1 [@richterRecurrentMutationID32012a; @zhangGeneticHeterogeneityDiffuse2013]
S1PR2 1 [@muppidiLossSignalingGa132014b; @morinFrequentMutationHistonemodifying2011]
SGK1 1 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@morinFrequentMutationHistonemodifying2011]
SIN3A 1 [@chapuyMolecularSubtypesDiffuse2018b; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]
SMARCA2 1
SMARCA4 1 [@lohrDiscoveryPrioritizationSomatic2012a; @nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a]
SOCS1 1 Weniger et al[@wenigerMutationsTumorSuppressor2006a] [@morinFrequentMutationHistonemodifying2011]
SPEN 1 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@albuquerqueEnhancingKnowledgeDiscovery2017a; @rossiCodingGenomeSplenic2012c]
STAT3 1 [@lohrDiscoveryPrioritizationSomatic2012a]
STAT6 1 Ritz et al[@ritzRecurrentMutationsSTAT62009a] [@yildizActivatingSTAT6Mutations2015c]
TAP1 1 [@schmitzGeneticsPathogenesisDiffuse2018a]
TBL1XR1 1 [@rossiCodingGenomeSplenic2012c; @lohrDiscoveryPrioritizationSomatic2012a]
TCF3 1 [@schmitzBurkittLymphomaPathogenesis2012]
TET3 1
TMSB4X 1 [@albuquerqueEnhancingKnowledgeDiscovery2017a]
TNFAIP3 1 Schmitz et al[@schmitzTNFAIP3A20Tumor2009a] [@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a]
TNFRSF1B 1
TP53 1 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] [@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004; @morinFrequentMutationHistonemodifying2011]
TRAF3 1 Otto et al[@ottoGeneticLesionsTRAF32012a] [@pasqualucciAnalysisCodingGenome2011; @rossiAlterationBIRC3Multiple2011a]
UBE2A 1 Reichel et al[@reichelFlowSortingExome2015a] [@lohrDiscoveryPrioritizationSomatic2012a]
UBR5 1 [@zhangGeneticHeterogeneityDiffuse2013; @pararajalingamCodingNoncodingDrivers2020]
UNC5C 1 [@lohrDiscoveryPrioritizationSomatic2012a]
VPS13B 1 [@lohrDiscoveryPrioritizationSomatic2012a]
WEE1 1 Reichel et al[@reichelFlowSortingExome2015a] [@schmitzGeneticsPathogenesisDiffuse2018a]
XPO1 1 Jardin et al[@jardinRecurrentMutationsExportin2016a] [@mareschalWholeExomeSequencing2016]
ZFP36L1 1 Reichel et al[@reichelFlowSortingExome2015a] [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]

Tier 2 PMBL genes

82 total

Gene Tier First PMBL evidence Other entities
ABCA13 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@spinaGeneticsNodalMarginal2016b]
ACTG1 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@spinaGeneticsNodalMarginal2016b; @hubschmannMutationalMechanismsShaping2021b]
AKAP6 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
ARIH2 2 Reichel et al[@reichelFlowSortingExome2015a]
AXDND1 2 Gomez et al[@gomezUltraDeepSequencingReveals2023]
BCL2 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@tanakaFrequentIncidenceSomatic1992; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]
BCL7A 2 Reichel et al[@reichelFlowSortingExome2015a] [@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @zhangGeneticHeterogeneityDiffuse2013]
BIRC3 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018]
CCND3 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@morinFrequentMutationHistonemodifying2011; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]
CDH2 2 Desch et al[@deschGenotypingCirculatingTumor2020]
CDH5 2 Gomez et al[@gomezUltraDeepSequencingReveals2023]
CXCR5 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@schmitzGeneticsPathogenesisDiffuse2018a]
DGKB 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
DMD 2 Reichel et al[@reichelFlowSortingExome2015a]
DNAH12 2 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b]
EGR1 2 Reichel et al[@reichelFlowSortingExome2015a] [@rossiCodingGenomeSplenic2012c; @krysiakRecurrentSomaticMutations2017b]
EPHA7 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@zhangGeneticHeterogeneityDiffuse2013]
EZR 2 Desch et al[@deschGenotypingCirculatingTumor2020]
FOXO1 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011]
GCSAM 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
GPR126 2 Weniger et al[@wenigerMutationsTumorSuppressor2006a]
HECW2 2 Reichel et al[@reichelFlowSortingExome2015a]
HELLS 2 Reichel et al[@reichelFlowSortingExome2015a]
HIST1H2BC 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@krysiakRecurrentSomaticMutations2017b; @lohrDiscoveryPrioritizationSomatic2012a]
HIST1H3B 2 Reichel et al[@reichelFlowSortingExome2015a] [@lohrDiscoveryPrioritizationSomatic2012a]
HIST1H4C 2 Reichel et al[@reichelFlowSortingExome2015a]
HIST1H4E 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
HIST1H4J 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@paneaWholeGenomeLandscape2019]
HLA-A 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@lohrDiscoveryPrioritizationSomatic2012a]
HLA-C 2 Gomez et al[@gomezUltraDeepSequencingReveals2023] [@chapuyMolecularSubtypesDiffuse2018b]
HRNR 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b]
IGLL5 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @chapuyMolecularSubtypesDiffuse2018b]
IKBKB 2 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] [@reddyGeneticFunctionalDrivers2017; @rossiAlterationBIRC3Multiple2011a]
IL13RA1 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
IL1RAPL2 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
IRF2BP2 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
IRF4 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@morinFrequentMutationHistonemodifying2011]
ITGB2 2
ITPR3 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] [@loveGeneticLandscapeMutations2012]
JUNB 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@reddyGeneticFunctionalDrivers2017]
KLF2 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@pasqualucciAnalysisCodingGenome2011; @jalladesExomeSequencingIdentifies2017]
KMT2D 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]
LIMD2 2 Gomez et al[@gomezUltraDeepSequencingReveals2023]
LPHN3 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b]
LRRN3 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@zhangGeneticHeterogeneityDiffuse2013]
MAGEC2 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
MCL1 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@reddyGeneticFunctionalDrivers2017; @paneaWholeGenomeLandscape2019]
MFHAS1 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a]
MPDZ 2 Reichel et al[@reichelFlowSortingExome2015a] [@morinMutationalStructuralAnalysis2013]
MYB 2 Desch et al[@deschGenotypingCirculatingTumor2020] [@reddyGeneticFunctionalDrivers2017]
MYC 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@pasqualucciHypermutationMultipleProtooncogenes2001a; @johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017]
NCOR2 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b]
NEK1 2 Reichel et al[@reichelFlowSortingExome2015a]
NFKB2 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@reddyGeneticFunctionalDrivers2017]
NSD2 2 [@zhangGeneticHeterogeneityDiffuse2013; @beaLandscapeSomaticMutations2013]
NUP214 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
OR13C2 2 Gomez et al[@gomezUltraDeepSequencingReveals2023]
PCBP1 2 [@schmitzBurkittLymphomaPathogenesis2012]
PCDH7 2 [@zhangGeneticHeterogeneityDiffuse2013]
PRUNE2 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
RANBP2 2 Reichel et al[@reichelFlowSortingExome2015a]
RBM38 2 Wienand et al[@wienandGenomicAnalysesFlowsorted2019b]
RDH12 2
RELN 2 Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] [@zhangGeneticHeterogeneityDiffuse2013]
RFTN1 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b] [@arthurGenomewideDiscoverySomatic2018]
RGS1 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] [@zhangGeneticHeterogeneityDiffuse2013]
SCN9A 2
SENP7 2 Reichel et al[@reichelFlowSortingExome2015a]
SETD5 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] [@reddyGeneticFunctionalDrivers2017]
SETDB1 2 Reichel et al[@reichelFlowSortingExome2015a]
SIAH2 2 Reichel et al[@reichelFlowSortingExome2015a] [@hubschmannMutationalMechanismsShaping2021b]
SMAD3 2
STAT5B 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] [@zhangGeneticHeterogeneityDiffuse2013]
STRAP 2
TBC1D15 2 Reichel et al[@reichelFlowSortingExome2015a]
TICRR 2 Reichel et al[@reichelFlowSortingExome2015a]
TNIP1 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
TRIP11 2 Reichel et al[@reichelFlowSortingExome2015a] [@zhangGeneticHeterogeneityDiffuse2013]
VMP1 2 Mottok et al[@mottokIntegrativeGenomicAnalysis2019b]
WDR87 2 Duns et al[@dunsCharacterizationDLBCLPMBL2021b]
ZCCHC11 2 Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b]
ZNF217 2 Reichel et al[@reichelFlowSortingExome2015a] [@hubschmannMutationalMechanismsShaping2021b]

Tier 3 PMBL genes

0 total

Gene Tier First PMBL evidence Other entities

References