PMBL_genes - morinlab/LLMPP GitHub Wiki
title: 'PMBL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
Origins of PMBL genes
Tier 1 PMBL genes
76 total
Gene | Tier | First PMBL evidence | Other entities |
---|---|---|---|
ACTB | 1 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | [@lohrDiscoveryPrioritizationSomatic2012a] |
ARID1A | 1 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | [@rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b] |
ARID5B | 1 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | [@reddyGeneticFunctionalDrivers2017] |
B2M | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@pararajalingamCodingNoncodingDrivers2020; @morinFrequentMutationHistonemodifying2011] |
BIRC6 | 1 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@reddyGeneticFunctionalDrivers2017] |
BTG1 | 1 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011] |
CD58 | 1 | Schneider et al[@schneiderAlterationsCD58Gene2015a] | [@morinFrequentMutationHistonemodifying2011] |
CD83 | 1 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @morinMutationalStructuralAnalysis2013] |
CDKN2A | 1 | [@spinaGeneticsNodalMarginal2016b; @morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019] | |
CHD8 | 1 | [@grandeGenomewideDiscoverySomatic2019] | |
CIITA | 1 | Mottok et al[@mottokGenomicAlterationsCIITA2015b] | [@morinFrequentMutationHistonemodifying2011] |
CISH | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
CREBBP | 1 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @loveGeneticLandscapeMutations2012] |
CSF2RB | 1 | Reichel et al[@reichelFlowSortingExome2015a] | |
DDX3X | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@schmitzBurkittLymphomaPathogenesis2012; @reddyGeneticFunctionalDrivers2017] |
DTX1 | 1 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | [@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013] |
DUSP2 | 1 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@lohrDiscoveryPrioritizationSomatic2012a] |
EBF1 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@thomasGeneticSubgroupsInform2023; @bohleRoleEarlyBcell2013] |
EEF1A1 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@hubschmannMutationalMechanismsShaping2021b] |
ETS1 | 1 | [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011] | |
EWSR1 | 1 | [@pararajalingamCodingNoncodingDrivers2020] | |
EZH2 | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@morinSomaticMutationsAltering2010a; @loveGeneticLandscapeMutations2012] |
FAS | 1 | [@spinaGeneticsNodalMarginal2016b; @schollMutationsRegionFAS2007] | |
FAT1 | 1 | [@spinaGeneticsNodalMarginal2016b] | |
FAT4 | 1 | [@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013] | |
GNA13 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@morinFrequentMutationHistonemodifying2011; @loveGeneticLandscapeMutations2012] |
HIST1H1B | 1 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@chapuyMolecularSubtypesDiffuse2018b; @krysiakRecurrentSomaticMutations2017b] |
HIST1H1C | 1 | [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011] | |
HIST1H1D | 1 | [@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b] | |
HIST1H1E | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a] |
HLA-B | 1 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | [@lohrDiscoveryPrioritizationSomatic2012a] |
IL4R | 1 | Vigano et al[@viganoSomaticIL4RMutations2018b] | [@dunsCharacterizationDLBCLPMBL2021b] |
IRF8 | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019] |
ITPKB | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@schmitzGeneticsPathogenesisDiffuse2018a] |
JAK1 | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@zhangGeneticHeterogeneityDiffuse2013] |
KMT2C | 1 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019; @zhangGeneticHeterogeneityDiffuse2013] |
LTB | 1 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@chapuyMolecularSubtypesDiffuse2018b] |
MAP3K14 | 1 | Otto et al[@ottoGeneticLesionsTRAF32012a] | [@rossiAlterationBIRC3Multiple2011a] |
MS4A1 | 1 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@rushtonGeneticEvolutionaryPatterns2020] |
NFKBIA | 1 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | [@lakeMutationsNFKBIAEncoding2009; @russler-germainMutationsAssociatedProgression2023b] |
NFKBIE | 1 | Mansouri et al[@mansouriFrequentNFKBIEDeletions2016] | [@morinGeneticLandscapesRelapsed2016; @pararajalingamCodingNoncodingDrivers2020] |
OSBPL10 | 1 | [@zhangGeneticHeterogeneityDiffuse2013] | |
P2RY8 | 1 | [@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a] | |
PCLO | 1 | [@lohrDiscoveryPrioritizationSomatic2012a] | |
PHIP | 1 | ||
PIM1 | 1 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a] |
PIM2 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@arthurGenomewideDiscoverySomatic2018] |
PRKDC | 1 | [@hubschmannMutationalMechanismsShaping2021b; @schmitzGeneticsPathogenesisDiffuse2018a] | |
PTPN1 | 1 | Gunawardana et al[@gunawardanaRecurrentSomaticMutations2014c] | |
PTPRD | 1 | [@spinaGeneticsNodalMarginal2016b] | |
RHOA | 1 | [@richterRecurrentMutationID32012a; @zhangGeneticHeterogeneityDiffuse2013] | |
S1PR2 | 1 | [@muppidiLossSignalingGa132014b; @morinFrequentMutationHistonemodifying2011] | |
SGK1 | 1 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@morinFrequentMutationHistonemodifying2011] |
SIN3A | 1 | [@chapuyMolecularSubtypesDiffuse2018b; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c] | |
SMARCA2 | 1 | ||
SMARCA4 | 1 | [@lohrDiscoveryPrioritizationSomatic2012a; @nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a] | |
SOCS1 | 1 | Weniger et al[@wenigerMutationsTumorSuppressor2006a] | [@morinFrequentMutationHistonemodifying2011] |
SPEN | 1 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@albuquerqueEnhancingKnowledgeDiscovery2017a; @rossiCodingGenomeSplenic2012c] |
STAT3 | 1 | [@lohrDiscoveryPrioritizationSomatic2012a] | |
STAT6 | 1 | Ritz et al[@ritzRecurrentMutationsSTAT62009a] | [@yildizActivatingSTAT6Mutations2015c] |
TAP1 | 1 | [@schmitzGeneticsPathogenesisDiffuse2018a] | |
TBL1XR1 | 1 | [@rossiCodingGenomeSplenic2012c; @lohrDiscoveryPrioritizationSomatic2012a] | |
TCF3 | 1 | [@schmitzBurkittLymphomaPathogenesis2012] | |
TET3 | 1 | ||
TMSB4X | 1 | [@albuquerqueEnhancingKnowledgeDiscovery2017a] | |
TNFAIP3 | 1 | Schmitz et al[@schmitzTNFAIP3A20Tumor2009a] | [@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a] |
TNFRSF1B | 1 | ||
TP53 | 1 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | [@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004; @morinFrequentMutationHistonemodifying2011] |
TRAF3 | 1 | Otto et al[@ottoGeneticLesionsTRAF32012a] | [@pasqualucciAnalysisCodingGenome2011; @rossiAlterationBIRC3Multiple2011a] |
UBE2A | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@lohrDiscoveryPrioritizationSomatic2012a] |
UBR5 | 1 | [@zhangGeneticHeterogeneityDiffuse2013; @pararajalingamCodingNoncodingDrivers2020] | |
UNC5C | 1 | [@lohrDiscoveryPrioritizationSomatic2012a] | |
VPS13B | 1 | [@lohrDiscoveryPrioritizationSomatic2012a] | |
WEE1 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@schmitzGeneticsPathogenesisDiffuse2018a] |
XPO1 | 1 | Jardin et al[@jardinRecurrentMutationsExportin2016a] | [@mareschalWholeExomeSequencing2016] |
ZFP36L1 | 1 | Reichel et al[@reichelFlowSortingExome2015a] | [@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011] |
Tier 2 PMBL genes
82 total
Gene | Tier | First PMBL evidence | Other entities |
---|---|---|---|
ABCA13 | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@spinaGeneticsNodalMarginal2016b] |
ACTG1 | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@spinaGeneticsNodalMarginal2016b; @hubschmannMutationalMechanismsShaping2021b] |
AKAP6 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
ARIH2 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
AXDND1 | 2 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | |
BCL2 | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@tanakaFrequentIncidenceSomatic1992; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011] |
BCL7A | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @zhangGeneticHeterogeneityDiffuse2013] |
BIRC3 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018] |
CCND3 | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@morinFrequentMutationHistonemodifying2011; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a] |
CDH2 | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | |
CDH5 | 2 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | |
CXCR5 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@schmitzGeneticsPathogenesisDiffuse2018a] |
DGKB | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
DMD | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
DNAH12 | 2 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | |
EGR1 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@rossiCodingGenomeSplenic2012c; @krysiakRecurrentSomaticMutations2017b] |
EPHA7 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@zhangGeneticHeterogeneityDiffuse2013] |
EZR | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | |
FOXO1 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] |
GCSAM | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
GPR126 | 2 | Weniger et al[@wenigerMutationsTumorSuppressor2006a] | |
HECW2 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
HELLS | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
HIST1H2BC | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@krysiakRecurrentSomaticMutations2017b; @lohrDiscoveryPrioritizationSomatic2012a] |
HIST1H3B | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@lohrDiscoveryPrioritizationSomatic2012a] |
HIST1H4C | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
HIST1H4E | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
HIST1H4J | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@paneaWholeGenomeLandscape2019] |
HLA-A | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@lohrDiscoveryPrioritizationSomatic2012a] |
HLA-C | 2 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | [@chapuyMolecularSubtypesDiffuse2018b] |
HRNR | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | |
IGLL5 | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @chapuyMolecularSubtypesDiffuse2018b] |
IKBKB | 2 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | [@reddyGeneticFunctionalDrivers2017; @rossiAlterationBIRC3Multiple2011a] |
IL13RA1 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
IL1RAPL2 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
IRF2BP2 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
IRF4 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@morinFrequentMutationHistonemodifying2011] |
ITGB2 | 2 | ||
ITPR3 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | [@loveGeneticLandscapeMutations2012] |
JUNB | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@reddyGeneticFunctionalDrivers2017] |
KLF2 | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@pasqualucciAnalysisCodingGenome2011; @jalladesExomeSequencingIdentifies2017] |
KMT2D | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019] |
LIMD2 | 2 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | |
LPHN3 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | |
LRRN3 | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@zhangGeneticHeterogeneityDiffuse2013] |
MAGEC2 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
MCL1 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@reddyGeneticFunctionalDrivers2017; @paneaWholeGenomeLandscape2019] |
MFHAS1 | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | |
MPDZ | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@morinMutationalStructuralAnalysis2013] |
MYB | 2 | Desch et al[@deschGenotypingCirculatingTumor2020] | [@reddyGeneticFunctionalDrivers2017] |
MYC | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@pasqualucciHypermutationMultipleProtooncogenes2001a; @johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017] |
NCOR2 | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b] |
NEK1 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
NFKB2 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@reddyGeneticFunctionalDrivers2017] |
NSD2 | 2 | [@zhangGeneticHeterogeneityDiffuse2013; @beaLandscapeSomaticMutations2013] | |
NUP214 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
OR13C2 | 2 | Gomez et al[@gomezUltraDeepSequencingReveals2023] | |
PCBP1 | 2 | [@schmitzBurkittLymphomaPathogenesis2012] | |
PCDH7 | 2 | [@zhangGeneticHeterogeneityDiffuse2013] | |
PRUNE2 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
RANBP2 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
RBM38 | 2 | Wienand et al[@wienandGenomicAnalysesFlowsorted2019b] | |
RDH12 | 2 | ||
RELN | 2 | Sarkozy et al[@sarkozyMutationalLandscapeGray2021a] | [@zhangGeneticHeterogeneityDiffuse2013] |
RFTN1 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | [@arthurGenomewideDiscoverySomatic2018] |
RGS1 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | [@zhangGeneticHeterogeneityDiffuse2013] |
SCN9A | 2 | ||
SENP7 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
SETD5 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | [@reddyGeneticFunctionalDrivers2017] |
SETDB1 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
SIAH2 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@hubschmannMutationalMechanismsShaping2021b] |
SMAD3 | 2 | ||
STAT5B | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | [@zhangGeneticHeterogeneityDiffuse2013] |
STRAP | 2 | ||
TBC1D15 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
TICRR | 2 | Reichel et al[@reichelFlowSortingExome2015a] | |
TNIP1 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
TRIP11 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@zhangGeneticHeterogeneityDiffuse2013] |
VMP1 | 2 | Mottok et al[@mottokIntegrativeGenomicAnalysis2019b] | |
WDR87 | 2 | Duns et al[@dunsCharacterizationDLBCLPMBL2021b] | |
ZCCHC11 | 2 | Tiacci et al[@tiacciPervasiveMutationsJAKSTAT2018b] | |
ZNF217 | 2 | Reichel et al[@reichelFlowSortingExome2015a] | [@hubschmannMutationalMechanismsShaping2021b] |
Tier 3 PMBL genes
0 total
Gene | Tier | First PMBL evidence | Other entities |
---|