---

title: 'PMBL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of PMBL genes

Tier 1, high-confidence PMBL genes

46 total

Gene	Summary	First PMBL study	Other entities	QC result
ACTB	Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], aSHM	Wienand et al	[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012]
ARID1A	Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@barisicARID1AOrchestratesSWI2024]	Wienand et al	[@krysiakRecurrentSomaticMutations2017; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]
ARID5B	Tier 1 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al	[@reddyGeneticFunctionalDrivers2017]
B2M	Tier 1 GE[@reichelFlowSortingExome2015], FE[@challa-malladiCombinedGeneticInactivation2011]	Reichel et al	[@morinFrequentMutationHistonemodifying2011; @pararajalingamCodingNoncodingDrivers2020]
BIRC6	Tier 1 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@reddyGeneticFunctionalDrivers2017]
BTG1	Tier 1 GE[@sarkozyMutationalLandscapeGray2021], FE[@almasmoumFrequentLossBTG12021], aSHM	Sarkozy et al	[@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]
CD58	Tier 1 GE[@schneiderAlterationsCD58Gene2015], FE[@challa-malladiCombinedGeneticInactivation2011]	Schneider et al	[@morinFrequentMutationHistonemodifying2011]
CD83	Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM	Duns et al	[@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]
CIITA	Tier 1 GE[@mottokGenomicAlterationsCIITA2015], FE[@mottokGenomicAlterationsCIITA2015], aSHM	Mottok et al	[@morinFrequentMutationHistonemodifying2011]
CISH	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
CREBBP	Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011]	Duns et al	[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011]
CSF2RB	Tier 1 GE[@reichelFlowSortingExome2015]	Reichel et al
DDX3X	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@gongSequentialInverseDysregulation2021]	Mottok et al	[@reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]
DTX1	Tier 1 GE[@gomezUltraDeepSequencingReveals2023], aSHM	Gomez et al	[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]
DUSP2	Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM	Duns et al	[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012]
EBF1	Tier 1 GE[@reichelFlowSortingExome2015], FE[@ramirez-komoSpontaneousLossLineage2017], aSHM	Reichel et al	[@bohleRoleEarlyBcell2013; @drevalGeneticSubdivisionsFollicular2023; @thomasGeneticSubgroupsInform2023]
EEF1A1	Tier 1 GE[@reichelFlowSortingExome2015]	Reichel et al	[@chapuyMolecularSubtypesDiffuse2018; @hubschmannMutationalMechanismsShaping2021]
EZH2	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@sneeringerCoordinatedActivitiesWildtype2010]	Mottok et al	[@loveGeneticLandscapeMutations2012; @morinSomaticMutationsAltering2010]
GNA13	Tier 1 GE[@reichelFlowSortingExome2015], FE[@muppidiLossSignalingGa132014]	Reichel et al	[@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
HIST1H1B	Tier 1 GE[@sarkozyMutationalLandscapeGray2021], aSHM	Sarkozy et al	[@chapuyMolecularSubtypesDiffuse2018; @krysiakRecurrentSomaticMutations2017]
HIST1H1E	Tier 1 GE[@reichelFlowSortingExome2015], aSHM	Reichel et al	[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @lohrDiscoveryPrioritizationSomatic2012]
HLA-B	Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@fangazioGeneticMechanismsHLAI2021]	Wienand et al	[@lohrDiscoveryPrioritizationSomatic2012]
IL4R	Tier 1 GE[@viganoSomaticIL4RMutations2018], FE[@viganoSomaticIL4RMutations2018], aSHM	Vigano et al	[@dunsCharacterizationDLBCLPMBL2021]
IRF8	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@qiuIRF8mutantCellLymphoma2024], aSHM	Mottok et al	[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
ITPKB	Tier 1 GE[@reichelFlowSortingExome2015], FE[@tiacciPervasiveMutationsJAKSTAT2018], aSHM	Reichel et al	[@drevalGeneticSubdivisionsFollicular2023; @schmitzGeneticsPathogenesisDiffuse2018]
JAK1	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@reddyGeneticFunctionalDrivers2017]
KMT2C	Tier 1 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@zhangGeneticHeterogeneityDiffuse2013; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]
LTB	Tier 1 GE[@deschGenotypingCirculatingTumor2020], aSHM	Desch et al	[@chapuyMolecularSubtypesDiffuse2018; @drevalGeneticSubdivisionsFollicular2023]
MAP3K14	Tier 1 GE[@ottoGeneticLesionsTRAF32012]	Otto et al	[@rossiAlterationBIRC3Multiple2011]
MS4A1	Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@rushtonGeneticEvolutionaryPatterns2020], aSHM	Mottok et al	[@rushtonGeneticEvolutionaryPatterns2020]
NFKBIA	Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@jungnickelClonalDeleteriousMutations2000]	Wienand et al	[@russler-germainMutationsAssociatedProgression2023; @thomasMutationalAnalysisIkappaBalpha2004]
NFKBIE	Tier 1 GE[@mansouriFrequentNFKBIEDeletions2016], FE[@mansouriFunctionalLossIkBe2015]	Mansouri et al	[@morinGeneticLandscapesRelapsed2016; @pararajalingamCodingNoncodingDrivers2020]
PIM1	Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@kuoRolePIM1Ibrutinibresistant2016], aSHM	Duns et al	[@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @pasqualucciHypermutationMultipleProtooncogenes2001]
PIM2	Tier 1 GE[@reichelFlowSortingExome2015], aSHM	Reichel et al	[@reddyGeneticFunctionalDrivers2017]
PTPN1	Tier 1 GE[@gunawardanaRecurrentSomaticMutations2014]	Gunawardana et al
SGK1	Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@gaoSGK1MutationsDLBCL2021], aSHM	Duns et al	[@morinFrequentMutationHistonemodifying2011]
SOCS1	Tier 1 GE[@wenigerMutationsTumorSuppressor2006], FE[@melznerBiallelicMutationSOCS12005], aSHM	Weniger et al	[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]
SPEN	Tier 1 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@albuquerqueEnhancingKnowledgeDiscovery2017; @rossiCodingGenomeSplenic2012]
STAT6	Tier 1 GE[@ritzRecurrentMutationsSTAT62009], FE[@mentzPARP14NovelTarget2022]	Ritz et al	[@yildizActivatingSTAT6Mutations2015]
TNFAIP3	Tier 1 GE[@schmitzTNFAIP3A20Tumor2009], FE[@compagnoMutationsMultipleGenes2009]	Schmitz et al	[@compagnoMutationsMultipleGenes2009; @drevalGeneticSubdivisionsFollicular2023; @rossiAlterationBIRC3Multiple2011]
TP53	Tier 1 GE[@tiacciPervasiveMutationsJAKSTAT2018], FE[@katoUnderstandingFunctionstructureFunctionmutation2003]	Tiacci et al	[@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012; @wildaInactivationARFMDM2p53Pathway2004]
TRAF3	Tier 1 GE[@ottoGeneticLesionsTRAF32012]	Otto et al	[@pasqualucciAnalysisCodingGenome2011; @rossiAlterationBIRC3Multiple2011]
UBE2A	Tier 1 GE[@reichelFlowSortingExome2015]	Reichel et al	[@lohrDiscoveryPrioritizationSomatic2012]
WEE1	Tier 1 GE[@reichelFlowSortingExome2015]	Reichel et al	[@schmitzGeneticsPathogenesisDiffuse2018]
XPO1	Tier 1 GE[@jardinRecurrentMutationsExportin2016], FE[@miloudiXPO1E571KMutationModifies2020]	Jardin et al	[@mareschalWholeExomeSequencing2016]
ZFP36L1	Tier 1 GE[@reichelFlowSortingExome2015], aSHM	Reichel et al	[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]

Tier 2, low-confidence PMBL genes

112 total

Gene	Summary	First PMBL study	Other entities	QC result
ABCA13	Tier 2 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@spinaGeneticsNodalMarginal2016]
ACTG1	Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM	Desch et al	[@fanComprehensiveCharacterizationDriver2020; @hubschmannMutationalMechanismsShaping2021; @spinaGeneticsNodalMarginal2016]
AKAP6	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
ARIH2	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
AXDND1	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
BCL2	Tier 2 GE[@sarkozyMutationalLandscapeGray2021], aSHM	Sarkozy et al	[@burkhardtClinicalRelevanceMolecular2022; @morinFrequentMutationHistonemodifying2011; @tanakaFrequentIncidenceSomatic1992]
BCL7A	Tier 2 GE[@reichelFlowSortingExome2015], FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM	Reichel et al	[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @morinFrequentMutationHistonemodifying2011]
BIRC3	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM	Duns et al	[@arthurGenomewideDiscoverySomatic2018; @beaLandscapeSomaticMutations2013; @rossiAlterationBIRC3Multiple2011]
CCND3	Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@schmitzBurkittLymphomaPathogenesis2012]	Desch et al	[@jalladesExomeSequencingIdentifies2017; @morinFrequentMutationHistonemodifying2011; @richterRecurrentMutationID32012]
CDH2	Tier 2 GE[@deschGenotypingCirculatingTumor2020]	Desch et al
CDH5	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
CDKN2A	Tier 2 GE, FE[@kannengiesserFunctionalStructuralGenetic2009]		[@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013; @spinaGeneticsNodalMarginal2016]
CHD8	Tier 2 GE		[@grandeGenomewideDiscoverySomatic2019]
CXCR5	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@schmitzGeneticsPathogenesisDiffuse2018]
DGKB	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
DMD	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
DNAH12	Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]	Wienand et al
EGR1	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al	[@krysiakRecurrentSomaticMutations2017; @rossiCodingGenomeSplenic2012]
EPHA7	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@zhangGeneticHeterogeneityDiffuse2013]
ETS1	Tier 2 GE, aSHM		[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
EWSR1	Tier 2 GE		[@pararajalingamCodingNoncodingDrivers2020]
EZR	Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM	Desch et al
FAS	Tier 2 GE, FE[@wangFasFADDDeathDomain2010]		[@morinFrequentMutationHistonemodifying2011; @schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016]
FAT1	Tier 2 GE		[@spinaGeneticsNodalMarginal2016]
FAT4	Tier 2 GE		[@morinMutationalStructuralAnalysis2013; @parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]
FOXO1	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@trinhAnalysisFOXO1Mutations]	Duns et al	[@morinFrequentMutationHistonemodifying2011; @schmitzBurkittLymphomaPathogenesis2012]
GCSAM	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
GPR126	Tier 2 GE[@wenigerMutationsTumorSuppressor2006]	Weniger et al
HECW2	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
HELLS	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
HIST1H1C	Tier 2 GE, aSHM		[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
HIST1H1D	Tier 2 GE, aSHM		[@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013]
HIST1H2BC	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019], aSHM	Mottok et al	[@krysiakRecurrentSomaticMutations2017; @lohrDiscoveryPrioritizationSomatic2012]
HIST1H3B	Tier 2 GE[@reichelFlowSortingExome2015], aSHM	Reichel et al	[@lohrDiscoveryPrioritizationSomatic2012]
HIST1H4C	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
HIST1H4E	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
HIST1H4J	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@paneaWholeGenomeLandscape2019]
HLA-A	Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@fangazioGeneticMechanismsHLAI2021]	Desch et al	[@lohrDiscoveryPrioritizationSomatic2012]
HLA-C	Tier 2 GE[@gomezUltraDeepSequencingReveals2023], FE[@fangazioGeneticMechanismsHLAI2021]	Gomez et al	[@chapuyMolecularSubtypesDiffuse2018]
HRNR	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]	Duns et al
IGLL5	Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM	Desch et al	[@chapuyMolecularSubtypesDiffuse2018; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]
IKBKB	Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]	Wienand et al	[@reddyGeneticFunctionalDrivers2017; @rossiAlterationBIRC3Multiple2011]
IL13RA1	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
IL1RAPL2	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
IRF2BP2	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
IRF4	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019], aSHM	Mottok et al	[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]
ITGB2	Tier 2 GE
ITPR3	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al	[@loveGeneticLandscapeMutations2012]
JUNB	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@lohrDiscoveryPrioritizationSomatic2012]
KLF2	Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM	Desch et al	[@drevalGeneticSubdivisionsFollicular2023; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]
KMT2D	Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@zhangDisruptionKMT2DPerturbs2015]	Desch et al	[@beaLandscapeSomaticMutations2013; @grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012]
LIMD2	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
LPHN3	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]	Duns et al
LRRN3	Tier 2 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@zhangGeneticHeterogeneityDiffuse2013]
MAGEC2	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
MCL1	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]	Duns et al	[@paneaWholeGenomeLandscape2019; @reddyGeneticFunctionalDrivers2017]
MFHAS1	Tier 2 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al
MPDZ	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al	[@morinMutationalStructuralAnalysis2013]
MYB	Tier 2 GE[@deschGenotypingCirculatingTumor2020]	Desch et al	[@reddyGeneticFunctionalDrivers2017]
MYC	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@freieGermlinePointMutation2024], aSHM	Duns et al	[@jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001]
NCOR2	Tier 2 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016]
NEK1	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
NFKB2	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@reddyGeneticFunctionalDrivers2017]
NSD2	Tier 2 GE		[@beaLandscapeSomaticMutations2013; @zhangGeneticHeterogeneityDiffuse2013]
NUP214	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
OR13C2	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
OSBPL10	Tier 2 GE, aSHM		[@zhangGeneticHeterogeneityDiffuse2013]
P2RY8	Tier 2 GE, FE[@muppidiLossSignalingGa132014]		[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @muppidiLossSignalingGa132014]
PCBP1	Tier 2 GE		[@schmitzBurkittLymphomaPathogenesis2012]
PCDH7	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al	[@zhangGeneticHeterogeneityDiffuse2013]
PCLO	Tier 2 GE		[@lohrDiscoveryPrioritizationSomatic2012]
PHIP	Tier 2 GE
PRKDC	Tier 2 GE		[@hubschmannMutationalMechanismsShaping2021; @schmitzGeneticsPathogenesisDiffuse2018]
PRUNE2	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
PTPRD	Tier 2 GE		[@drevalGeneticSubdivisionsFollicular2023; @spinaGeneticsNodalMarginal2016]
RANBP2	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
RBM38	Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]	Wienand et al
RDH12	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
RELN	Tier 2 GE[@sarkozyMutationalLandscapeGray2021]	Sarkozy et al	[@zhangGeneticHeterogeneityDiffuse2013]
RFTN1	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM	Duns et al	[@arthurGenomewideDiscoverySomatic2018]
RGS1	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al	[@zhangGeneticHeterogeneityDiffuse2013]
RHOA	Tier 2 GE, FE[@ohayreInactivatingMutationsGNA132016]		[@richterRecurrentMutationID32012; @zhangGeneticHeterogeneityDiffuse2013]
S1PR2	Tier 2 GE, FE[@muppidiLossSignalingGa132014], aSHM		[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014]
SCN9A	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
SENP7	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
SETD5	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al	[@reddyGeneticFunctionalDrivers2017]
SETDB1	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
SIAH2	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al	[@hubschmannMutationalMechanismsShaping2021]
SIN3A	Tier 2 GE		[@chapuyMolecularSubtypesDiffuse2018; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012]
SMAD3	Tier 2 GE
SMARCA2	Tier 2 GE
SMARCA4	Tier 2 GE, FE[@fernandoFunctionalCharacterizationSMARCA42020]		[@krysiakRecurrentSomaticMutations2017; @nadeuGenomicEpigenomicInsights2020; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012]
STAT3	Tier 2 GE, FE[@huNovelMissenseM206K2013]		[@morinFrequentMutationHistonemodifying2011]
STAT5B	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al	[@reddyGeneticFunctionalDrivers2017]
STRAP	Tier 2 GE[@gomezUltraDeepSequencingReveals2023]	Gomez et al
TAP1	Tier 2 GE		[@schmitzGeneticsPathogenesisDiffuse2018]
TBC1D15	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
TBL1XR1	Tier 2 GE, FE[@venturuttiTBL1XR1MutationsDrive2020]		[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @rossiCodingGenomeSplenic2012]
TCF3	Tier 2 GE		[@schmitzBurkittLymphomaPathogenesis2012]
TET3	Tier 2 GE
TICRR	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al
TMSB4X	Tier 2 GE, aSHM		[@drevalGeneticSubdivisionsFollicular2023; @reddyGeneticFunctionalDrivers2017]
TNFRSF1B	Tier 2 GE
TNIP1	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
TRIP11	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al	[@zhangGeneticHeterogeneityDiffuse2013]
UBR5	Tier 2 GE		[@albuquerqueEnhancingKnowledgeDiscovery2017; @pararajalingamCodingNoncodingDrivers2020]
UNC5C	Tier 2 GE		[@lohrDiscoveryPrioritizationSomatic2012]
VMP1	Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]	Mottok et al
VPS13B	Tier 2 GE
WDR87	Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]	Duns et al
ZCCHC11	Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]	Tiacci et al
ZNF217	Tier 2 GE[@reichelFlowSortingExome2015]	Reichel et al	[@hubschmannMutationalMechanismsShaping2021]

Tier 3, retired PMBL genes

0 total

Gene	Summary	First PMBL study	Other entities	QC result

References