TCF3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @schmitzBurkittLymphomaPathogenesis2012,
Experimental Evidence
Driver mutations affecting this gene in BL have been experimentally demonstrated to cause a gain of function (GOF).[@schmitzBurkittLymphomaPathogenesis2012]
Relevance tier by entity
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
BL
Mutation pattern and selective pressure estimates
TCF3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr19 | 1612366 | A>T | N551K |
| chr19 | 1612366 | A>C | N551K |
| chr19 | 1612349 | A>T | V557E |
| chr19 | 1612344 | C>T | V559M |
| chr19 | 1612337 | T>A | D561V |
| chr19 | 1612336 | A>T | D561E |
| chr19 | 1612336 | A>C | D561E |
| chr19 | 1612329 | C>T | E564K |
include:tables/browser_TCF3.md
Expression
include:tables/mermaid_TCF3.md