TCF3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
TCF3
History
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timeline
title Publication timing
2012-10-04 : Schmitz : BL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence BL gene[@schmitzBurkittLymphomaPathogenesis2012] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 11.55 |
| BL | Thomas cohort | 11.00 |
| BL | Panea cohort | 9.90 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 4.463 | 34.108 |
| DLBCL | No | No | 1.567 | 0.000 |
| FL | No | No | 0.000 | 0.000 |
TCF3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr19 | 1612366 | A>T | N551K |
| chr19 | 1612366 | A>C | N551K |
| chr19 | 1612349 | A>T | V557E |
| chr19 | 1612344 | C>T | V559M |
| chr19 | 1612337 | T>A | D561V |
| chr19 | 1612336 | A>T | D561E |
| chr19 | 1612336 | A>C | D561E |
| chr19 | 1612329 | C>T | E564K |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TCF3 Expression
