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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

PRKDC

History

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timeline
    title Publication timing
      2018-04-12 : Schmitz : DLBCL
      2021-05-05 : Hübschmann : FL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene
	1	high-confidence DLBCL gene [@schmitzGeneticsPathogenesisDiffuse2018a]
	2	relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021b]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.68
DLBCL	Schmitz cohort	7.66
DLBCL	Reddy cohort	6.61
DLBCL	Chapuy cohort	6.41
FL	GAMBL genomes	3.00

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.571	0.939
DLBCL	No	No	1.076	0.000
FL	No	No	0.000	7.794

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

PRKDC Expression

All Mutations

SP192833 SP116701 SP59304 SP192765 SP194065 SP116720

References