VPS13B - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
VPS13B
Relevance tier by entity
Entity |
Tier |
Description |
![PMBL](https://github.com/morinlab/LLMPP/wiki/images/icons/PMBL_tier1.png) |
1 |
high-confidence PMBL/cHL/GZL gene |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012a] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
4.21 |
DLBCL |
Schmitz cohort |
8.30 |
DLBCL |
Reddy cohort |
5.71 |
DLBCL |
Chapuy cohort |
4.27 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.768 |
0.000 |
DLBCL |
No |
No |
1.730 |
0.000 |
FL |
No |
No |
0.000 |
4.014 |
VPS13B Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr8 |
100829860 |
A>T |
Q2755H |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/VPS13B_NM_152564.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/VPS13B.svg)
VPS13B Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/VPS13B_by_pathology.svg)
References