TP53 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
TP53
History
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timeline
title Publication timing
2004-03-01 : Wilda : BL
2011-07-27 : Morin : FL
2012-08-27 : Rossi : MZL
2013-11-05 : Be : MCL
2018-05-31 : Tiacci : PMBL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene[@rossiCodingGenomeSplenic2012c] |
 |
1 | high-confidence PMBL/cHL/GZL gene[@tiacciPervasiveMutationsJAKSTAT2018b] |
 |
1 | high-confidence BL gene [@wildaInactivationARFMDM2p53Pathway2004] |
 |
1 | high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012a] |
 |
1 | high-confidence FL gene [@morinFrequentMutationHistonemodifying2011] |
 |
1 | high-confidence MCL gene [@beaLandscapeSomaticMutations2013] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 45.50 |
| BL | Thomas cohort | 41.90 |
| BL | Panea cohort | 43.60 |
| DLBCL | GAMBL genomes | 27.53 |
| DLBCL | Schmitz cohort | 22.34 |
| DLBCL | Reddy cohort | 10.91 |
| DLBCL | Chapuy cohort | 21.37 |
| FL | GAMBL genomes | 6.93 |
| MCL | GAMBL genomes | 9.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 83.783 | 58.309 |
| DLBCL | No | Yes | 127.531 | 143.760 |
| FL | No | Yes | 63.211 | 142.226 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TP53 Expression
