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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

PTPN1

History

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timeline
    title Publication timing
      2014-02-16 : Gunawardana : PMBL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene[@gunawardanaRecurrentSomaticMutations2014c]
	2-a	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	0.19
DLBCL	Schmitz cohort	1.06
DLBCL	Reddy cohort	1.40
DLBCL	Chapuy cohort	0.43

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	0	0
DLBCL	Yes	No	0	0
FL	Yes	No	0	0

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr20	49120482	49140477	TSS	active_promoter

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

PTPN1 Expression

References