PTPN1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @gunawardanaRecurrentSomaticMutations2014,
Relevance tier by entity
include:tables/table1_PTPN1.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 0.19 |
| DLBCL | Schmitz cohort | 1.06 |
| DLBCL | Reddy cohort | 1.40 |
| DLBCL | Chapuy cohort | 0.43 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 0 | 0 |
| DLBCL | Yes | No | 0 | 0 |
| FL | Yes | No | 0 | 0 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr20 | 49120482 | 49140477 | TSS | active_promoter |
include:tables/browser_PTPN1.md
Expression
include:tables/mermaid_PTPN1.md