S1PR2 - morinlab/LLMPP GitHub Wiki

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @muppidiLossSignalingGa132014, @morinMutationalStructuralAnalysis2013, @morinFrequentMutationHistonemodifying2011, @lohrDiscoveryPrioritizationSomatic2012,

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Overview

S1PR2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

Experimental Evidence

Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@muppidiLossSignalingGa132014]

Relevance tier by entity

include:tables/table1_S1PR2.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_S1PR2.md

FL

include:tables/FL_S1PR2.md

BL

include:tables/BL_S1PR2.md

Mutation pattern and selective pressure estimates

include:tables/dnds_S1PR2.md

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr19	10340142	10341764	TSS	active_promoter

include:tables/browser_S1PR2.md

Expression

include:tables/mermaid_S1PR2.md

References