S1PR2 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
S1PR2
Overview
S1PR2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
History
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
title Publication timing
2011-07-27 : Morin : DLBCL
2012-03-06 : Lohr : DLBCL
2013-08-15 : Morin : DLBCL
2014-12-11 : Muppidi : BL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![PMBL](https://github.com/morinlab/LLMPP/wiki/images/icons/PMBL_tier1.png) |
1 |
high-confidence PMBL/cHL/GZL gene |
![BL](https://github.com/morinlab/LLMPP/wiki/images/icons/BL_tier2.png) |
2 |
aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@muppidiLossSignalingGa132014b] |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
aSHM target and high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011; @lohrDiscoveryPrioritizationSomatic2012a; @morinMutationalStructuralAnalysis2013] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier1.png) |
1 |
aSHM target and high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
BL |
GAMBL genomes+capture |
1.15 |
BL |
Thomas cohort |
0.00 |
BL |
Panea cohort |
4.00 |
DLBCL |
GAMBL genomes |
4.78 |
DLBCL |
Schmitz cohort |
2.13 |
DLBCL |
Reddy cohort |
2.20 |
DLBCL |
Chapuy cohort |
2.56 |
FL |
GAMBL genomes |
6.24 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
Yes |
No |
0.000 |
0.000 |
DLBCL |
Yes |
Yes |
34.147 |
0.000 |
FL |
Yes |
Yes |
36.780 |
339.679 |
aSHM regions
chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
chr19 |
10340142 |
10341764 |
TSS |
active_promoter |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/S1PR2_NM_004230.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/S1PR2.svg)
S1PR2 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/S1PR2_by_pathology.svg)
References