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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

XPO1

History

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timeline
    title Publication timing
2017-10-10 : Reddy : DLBCL
      2016-03-01 : Mareschal : DLBCL
      2016-06-01 : Jardin : PMBL
2018-05-01 : Chapuy : DLBCL
2021-05-05 : Hubschmann : DLBCL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene[@jardinRecurrentMutationsExportin2016a]
	1	high-confidence DLBCL gene[@mareschalWholeExomeSequencing2016; @reddyGeneticFunctionalDrivers2017]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	3.82
DLBCL	Schmitz cohort	2.34
DLBCL	Reddy cohort	1.40
DLBCL	Chapuy cohort	1.28

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	1.028	0
DLBCL	No	No	9.927	0
FL	No	No	0.000	0

XPO1 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr2	61719471	T>C	E571G
chr2	61719472	C>T	E571K

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

XPO1 Expression

References