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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

BIRC3

History

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timeline
    title Publication timing
      2011-11-03 : Rossi : MZL
      2013-11-05 : Be : MCL
      2018-10-01 : Arthur : DLBCL
      2021-07-15 : Duns : PMBL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in PMBL/cHL/GZL not firmly established[@dunsCharacterizationDLBCLPMBL2021b]
	1	high-confidence MZL gene[@rossiAlterationBIRC3Multiple2011a]
	2-a	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]
	1-a	aSHM target and high-confidence MCL gene [@beaLandscapeSomaticMutations2013]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	1.53
DLBCL	Schmitz cohort	1.91
DLBCL	Reddy cohort	1.30
DLBCL	Chapuy cohort	1.71
MCL	GAMBL genomes	7.11

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	0.000	0
DLBCL	Yes	No	1.404	0
FL	Yes	No	2.427	0

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr11	102188170	102190077	TSS	active_promoter

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

BIRC3 Expression

References