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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

RFTN1

History

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timeline
    title Publication timing
      2018-10-01 : Arthur : DLBCL
      2021-07-15 : Duns : PMBL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in PMBL/cHL/GZL not firmly established[@dunsCharacterizationDLBCLPMBL2021b]
	2	relevance in MZL not firmly established
	2-a	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	4.59
DLBCL	Schmitz cohort	5.96
DLBCL	Reddy cohort	4.40
DLBCL	Chapuy cohort	4.70

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	1.080	0.000
DLBCL	Yes	No	3.636	3.809
FL	Yes	No	2.622	0.000

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr3	16546433	16556786	TSS	active_promoter-strong_enhancer

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

RFTN1 Expression

References