Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.¹ These mutations are common in DLBCL, BL and, to a lesser extent, FL.^2,3 FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.⁴

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timeline
    title Publication timing
      2011-07-27 : Morin : DLBCL
      2012-10-04 : Schmitz : BL
      2021-07-15 : Duns : PMBL

Entity	Tier	Description
	1	high-confidence MZL gene
	2	relevance in PMBL/cHL/GZL not firmly established[@dunsCharacterizationDLBCLPMBL2021b]
	1	high-confidence BL gene [@schmitzBurkittLymphomaPathogenesis2012]
	1	high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]
	1	high-confidence FL gene [@morinFrequentMutationHistonemodifying2011]

View coding variants in ProteinPaint hg19 or hg38

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