PCLO - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
PCLO
History
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timeline
title Publication timing
2012-03-06 : Lohr : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene |
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | relevance in DLBCL not firmly established[@lohrDiscoveryPrioritizationSomatic2012a] |
 |
1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 16.44 |
| DLBCL | Schmitz cohort | 21.28 |
| DLBCL | Reddy cohort | 15.12 |
| DLBCL | Chapuy cohort | 23.08 |
| FL | GAMBL genomes | 9.24 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 1.223 | 0.389 |
| FL | No | No | 0.000 | 0.000 |
PCLO Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr7 | 82585303 | G>T | L1656I |
| chr7 | 82585302 | A>G | L1656P |
| chr7 | 82544727 | T>C | K4192R |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
PCLO Expression
