PCLO - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
PCLO
History
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
title Publication timing
2012-03-06 : Lohr : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![MZL](https://github.com/morinlab/LLMPP/wiki/images/icons/MZL_tier1.png) |
1 |
high-confidence MZL gene |
![PMBL](https://github.com/morinlab/LLMPP/wiki/images/icons/PMBL_tier1.png) |
1 |
high-confidence PMBL/cHL/GZL gene |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier2.png) |
2 |
relevance in DLBCL not firmly established[@lohrDiscoveryPrioritizationSomatic2012a] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier1.png) |
1 |
high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
16.44 |
DLBCL |
Schmitz cohort |
21.28 |
DLBCL |
Reddy cohort |
15.12 |
DLBCL |
Chapuy cohort |
23.08 |
FL |
GAMBL genomes |
9.24 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.000 |
0.000 |
DLBCL |
No |
No |
1.223 |
0.389 |
FL |
No |
No |
0.000 |
0.000 |
PCLO Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr7 |
82585303 |
G>T |
L1656I |
chr7 |
82585302 |
A>G |
L1656P |
chr7 |
82544727 |
T>C |
K4192R |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/PCLO_NM_033026.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/PCLO.svg)
PCLO Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/PCLO_by_pathology.svg)
References