BIRC6 - morinlab/LLMPP GitHub Wiki

---

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @sarkozyMutationalLandscapeGray2021, @reddyGeneticFunctionalDrivers2017, @arthurGenomewideDiscoverySomatic2018,

TOC

Overview

BIRC6, as a negative regulator of non-canonical NF-κB signaling, is implicated in lymphomagenesis. Mutations in the BIRC6 have been found in DLBCL and grey zone lymphoma (GZL).[@sarkozyMutationalLandscapeGray2021],[@reddyGeneticFunctionalDrivers2017]

Relevance tier by entity

include:tables/table1_BIRC6.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_BIRC6.md

FL

include:tables/FL_BIRC6.md

Mutation pattern and selective pressure estimates

include:tables/dnds_BIRC6.md

BIRC6 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr2	32740138	T>A	C3550*

include:tables/browser_BIRC6.md

Expression

include:tables/mermaid_BIRC6.md

References