HIST1H1D - morinlab/LLMPP GitHub Wiki

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @jalladesExomeSequencingIdentifies2017, @chapuyMolecularSubtypesDiffuse2018, @morinMutationalStructuralAnalysis2013, @krysiakRecurrentSomaticMutations2017,

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Overview

This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017] Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.

Relevance tier by entity

include:tables/table1_HIST1H1D.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_HIST1H1D.md

BL

include:tables/BL_HIST1H1D.md

FL

include:tables/FL_HIST1H1D.md

Mutation pattern and selective pressure estimates

include:tables/dnds_HIST1H1D.md

include:tables/browser_HIST1H1D.md

include:tables/mermaid_HIST1H1D.md

References