Mutations in IL4R have been identified in various types of B-cell lymphomas, particularly primary mediastinal large B-cell lymphoma (PMBCL) and DLBCL. IL4R is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. IL4R mutations are found in approximately 24.2% of primary PMBCL cases. These mutations are commonly single nucleotide variants in exon 8, resulting in the I242N amino acid change. This leads to constitutive activation of the JAK-STAT signaling pathway and upregulation of downstream cytokine expression profiles and B cell-specific antigens.^1,2 In DLBCL, IL4R mutations are more rare and tend to occur within the GCB subgroup.²

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timeline
    title Publication timing
      2018-05-03 : Vigan : PMBL
      2021-07-15 : Duns : DLBCL

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene[@viganoSomaticIL4RMutations2018b]
	1-a	aSHM target and high-confidence DLBCL gene[@dunsCharacterizationDLBCLPMBL2021b]

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