STAT5B - morinlab/LLMPP GitHub Wiki


bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @reddyGeneticFunctionalDrivers2017, @tiacciPervasiveMutationsJAKSTAT2018, @zhangGeneticHeterogeneityDiffuse2013,

TOC

Overview

Mutations in this gene were first described in DLBCL in 2013[@zhangGeneticHeterogeneityDiffuse2013] and by the same group in a subsequent study.[@reddyGeneticFunctionalDrivers2017] It remains in Tier 2 because other exome and genome-wide studies of DLBCL did not reproduce this observation.

Relevance tier by entity

include:tables/table1_STAT5B.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 0.57
DLBCL Schmitz cohort 0.43
DLBCL Reddy cohort 1.60
DLBCL Chapuy cohort 0.43

Mutation pattern and selective pressure estimates

include:tables/dnds_STAT5B.md

include:tables/browser_STAT5B.md

Expression

include:tables/mermaid_STAT5B.md

References