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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

NCOR2

Overview

Mutations in this gene are relatively rare in DLBCL overall but show a pattern of inactivation.

History

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timeline
    title Publication timing
      2012-10-04 : Schmitz : BL
      2016-09-08 : Spina : MZL
      2021-04-01 : Sarkozy : PMBL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021a]
	1	high-confidence MZL gene[@spinaGeneticsNodalMarginal2016b]
	2	relevance in BL not firmly established[@schmitzBurkittLymphomaPathogenesis2012]
	2	relevance in DLBCL not firmly established

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	6.24
BL	Thomas cohort	NA
BL	Panea cohort	NA
DLBCL	GAMBL genomes	2.10
DLBCL	Schmitz cohort	5.74
DLBCL	Reddy cohort	3.60
DLBCL	Chapuy cohort	4.27

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.551	0.000
DLBCL	No	No	1.376	4.613
FL	No	No	0.985	0.000

NCOR2 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

NCOR2 Expression

References