JUNB - morinlab/LLMPP GitHub Wiki

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @schuhmacherJUNBDUSP2SGK12019, @hubschmannMutationalMechanismsShaping2021, @reddyGeneticFunctionalDrivers2017, @drevalRevisitingReddyDLBCL2023, @mottokIntegrativeGenomicAnalysis2019,

TOC

Overview

JUNB has been reported to be frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL).[@schuhmacherJUNBDUSP2SGK12019] Mutations have also been reported in DLBCL but the mutation rate in the earliest study[@reddyGeneticFunctionalDrivers2017] was likely an over-estimate.[@drevalRevisitingReddyDLBCL2023] According to one study, mutations are often enriched at somatic hypermutation hotspot sites, indicating the involvement of aberrant somatic hypermutation in the pathogenesis of these lymphomas.[@schuhmacherJUNBDUSP2SGK12019]

Relevance tier by entity

include:tables/table1_JUNB.md

Warnings

<<Warn("The variants reported in this gene failed QC")>>

Mutations in this gene were reported to be inflated in the original results according to Dreval K

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_JUNB.md

Mutation pattern and selective pressure estimates

include:tables/dnds_JUNB.md

include:tables/browser_JUNB.md

Expression

include:tables/mermaid_JUNB.md

References