HIST1H3B - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @lohrDiscoveryPrioritizationSomatic2012, @reichelFlowSortingExome2015,
Overview
The relevance of HIST1H3B mutations in DLBCL remains unclear. Selective pressure analysis did not identify this gene as significantly enriched for either missense or truncating mutations, indicating that many of these mutations may represent passengers.
Relevance tier by entity
include:tables/table1_HIST1H3B.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
include:tables/DLBCL_HIST1H3B.md
BL
FL
Mutation pattern and selective pressure estimates
include:tables/dnds_HIST1H3B.md
HIST1H3B Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr6 | 26032045 | C>T | D82N |
| chr6 | 26032029 | C>G | S87T |
| chr6 | 26032029 | C>T | S87N |
| chr6 | 26032028 | G>C | S87R |
| chr6 | 26032021 | C>T | V90M |
| chr6 | 26032017 | A>G | M91T |
include:tables/browser_HIST1H3B.md
include:tables/mermaid_HIST1H3B.md