HIST1H3B - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
HIST1H3B
History
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timeline
title Publication timing
2013-01-01 : Zhang : DLBCL
2015-02-12 : Reichel : PMBL
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2 |
relevance in PMBL/cHL/GZL not firmly established[@reichelFlowSortingExome2015a] |
 |
1 |
high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012a] |
 |
1 |
high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| DLBCL |
GAMBL genomes |
2.10 |
| DLBCL |
Schmitz cohort |
1.70 |
| DLBCL |
Reddy cohort |
2.00 |
| DLBCL |
Chapuy cohort |
2.14 |
| FL |
GAMBL genomes |
1.62 |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
No |
No |
8.244 |
0.000 |
| DLBCL |
No |
No |
2.108 |
9.678 |
| FL |
No |
No |
1.637 |
0.000 |
HIST1H3B Hotspots
| Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
| chr6 |
26032045 |
C>T |
D82N |
| chr6 |
26032029 |
C>G |
S87T |
| chr6 |
26032029 |
C>T |
S87N |
| chr6 |
26032028 |
G>C |
S87R |
| chr6 |
26032021 |
C>T |
V90M |
| chr6 |
26032017 |
A>G |
M91T |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
References