P2RY8 - morinlab/LLMPP GitHub Wiki
P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.1 Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL2 and BL.1
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timeline
title Publication timing
2012-03-06 : Lohr : DLBCL
2014-12-11 : Muppidi : BL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence BL gene [@muppidiLossSignalingGa132014b] |
 |
1 | high-confidence DLBCL gene [@lohrDiscoveryPrioritizationSomatic2012a] |
 |
2 | relevance in FL not firmly established |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 6.93 |
| BL | Thomas cohort | 11.00 |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 6.88 |
| DLBCL | Schmitz cohort | 7.23 |
| DLBCL | Reddy cohort | NA |
| DLBCL | Chapuy cohort | 5.98 |
| FL | GAMBL genomes | 2.31 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 58.153 | 189.145 |
| DLBCL | No | Yes | 31.041 | 0.000 |
| FL | No | No | 23.117 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
