P2RY8 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @muppidiLossSignalingGa132014, @lohrDiscoveryPrioritizationSomatic2012
Overview
P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[@muppidiLossSignalingGa132014]
Experimental Evidence
Driver mutations affecting this gene in BL/DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@muppidiLossSignalingGa132014]
Relevance tier by entity
include:tables/table1_P2RY8.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
BL
Mutation pattern and selective pressure estimates
include:tables/browser_P2RY8.md
Expression
include:tables/mermaid_P2RY8.md