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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

FAT4

History

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timeline
    title Publication timing
      2013-08-15 : Morin : DLBCL
      2013-12-13 : Parry : MZL
      2014-05-08 : Zhang : MCL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene
	2	relevance in MZL not firmly established[@parryWholeExomeSequencing2013]
	2	relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]
	2	relevance in MCL not firmly established [@zhangGenomicLandscapeMantle2014]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	12.81
DLBCL	Schmitz cohort	20.43
DLBCL	Reddy cohort	14.91
DLBCL	Chapuy cohort	16.67
MCL	GAMBL genomes	3.79

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.000	0.000
DLBCL	No	No	1.682	4.189
FL	No	No	0.000	0.000

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

FAT4 Expression

All Mutations

DLBCL

RG014 RG038 RG043 RG055 RG077 RG081 RG111

References