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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

CXCR5

Overview

CXCR5 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. No notable hot spots have been described in this gene in the context of the cancers listed below. The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations.

History

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timeline
    title Publication timing
      2018-04-12 : Schmitz : DLBCL
      2019-09-05 : Mottok : PMBL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in PMBL/cHL/GZL not firmly established[@mottokIntegrativeGenomicAnalysis2019b]
	1-a	aSHM target and high-confidence DLBCL gene[@schmitzGeneticsPathogenesisDiffuse2018a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	1.91
DLBCL	Schmitz cohort	4.04
DLBCL	Reddy cohort	2.10
DLBCL	Chapuy cohort	1.71

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	2.351	0.000
DLBCL	Yes	No	1.785	0.000
FL	Yes	No	2.934	76.955

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr11	118754458	118756514	TSS	NA

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

CXCR5 Expression

References