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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

ARID5B

<<Warn("In a subsequent reanalysis, the mutation rate in this gene was found to be inflated in the original results")>>

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2017-10-10 : Reddy : DLBCL
      2018-10-01 : Arthur : DLBCL
      2023-11-15 : Gomez : PMBL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene[@gomezUltraDeepSequencingReveals2023]
	2	relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017;@drevalRevisitingReddyDLBCL2023; @arthurGenomewideDiscoverySomatic2018]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	3.25
DLBCL	Schmitz cohort	4.30
DLBCL	Reddy cohort	4.30
DLBCL	Chapuy cohort	2.60

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.378	0
DLBCL	No	No	2.263	0
FL	No	No	0.000	0

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

ARID5B Expression

Representative Mutations

Rating ★ ★ ★ ★ ☆

Rating ★ ★ ★ ★ ☆

All Mutations

Reddy_2057T Reddy_2073T Reddy_2213T Reddy_2215T Reddy_2216T Reddy_2241T Reddy_2270T Reddy_2278T Reddy_2478T Reddy_2481T Reddy_2540T Reddy_2562T Reddy_2611T Reddy_2677T Reddy_2688T Reddy_2764T Reddy_2785T Reddy_2788T Reddy_2831T Reddy_2865T Reddy_2897T Reddy_2905T Reddy_2921T Reddy_2944T Reddy_2948T Reddy_2950T Reddy_2955T Reddy_3412T Reddy_3418T Reddy_3523T Reddy_3535T Reddy_3537T Reddy_3586T Reddy_3608T Reddy_3625T Reddy_3628T Reddy_3646T Reddy_3655T Reddy_3699T Reddy_3711T Reddy_3732T Reddy_3733T Reddy_3755T Reddy_3760T Reddy_3810T Reddy_3832T Reddy_3837T Reddy_3842T Reddy_3845T Reddy_3856T Reddy_3959T Reddy_695T Reddy_800T Reddy_813T Reddy_830T

References