TNFAIP3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
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TNFAIP3
History
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timeline
title Publication timing
2009-05-11 : Schmitz : PMBL
2009-06-04 : Compagno : DLBCL
2011-11-03 : Rossi : MZL
2013-01-01 : Zhang : DLBCL
2017-05-01 : Albuquerque : DLBCL
2017-10-10 : Reddy : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
|
1 |
high-confidence PMBL/cHL/GZL gene[@schmitzTNFAIP3A20Tumor2009a] |
|
1 |
high-confidence MZL gene[@rossiAlterationBIRC3Multiple2011a] |
|
1 |
high-confidence DLBCL gene [@compagnoMutationsMultipleGenes2009a] |
|
1 |
high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
6.69 |
DLBCL |
Schmitz cohort |
16.60 |
DLBCL |
Reddy cohort |
8.11 |
DLBCL |
Chapuy cohort |
12.39 |
FL |
GAMBL genomes |
4.85 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
1.168 |
16.846 |
DLBCL |
No |
Yes |
1.550 |
30.319 |
FL |
No |
No |
5.686 |
75.953 |
TNFAIP3 Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr6 |
138197303 |
G>A |
E269K |
chr6 |
138198218 |
C>T |
R271* |
chr6 |
138198246 |
G>A |
R280Q |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TNFAIP3 Expression
References