TNFAIP3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @compagnoMutationsMultipleGenes2009, @schmitzTNFAIP3A20Tumor2009, @rossiAlterationBIRC3Multiple2011,
Experimental Evidence
Driver mutations affecting this gene in FL/DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@compagnoMutationsMultipleGenes2009]
Relevance tier by entity
include:tables/table1_TNFAIP3.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
include:tables/DLBCL_TNFAIP3.md
FL
Mutation pattern and selective pressure estimates
include:tables/dnds_TNFAIP3.md
TNFAIP3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr6 | 138197303 | G>A | E269K |
| chr6 | 138198218 | C>T | R271* |
| chr6 | 138198246 | G>A | R280Q |
include:tables/browser_TNFAIP3.md
Expression
include:tables/mermaid_TNFAIP3.md