SOCS1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
SOCS1
History
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timeline
title Publication timing
2006-04-27 : Weniger : PMBL
2011-07-27 : Morin : DLBCL
2012-03-06 : Lohr : DLBCL
2013-01-01 : Zhang : DLBCL
2013-08-15 : Morin : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-10-01 : Arthur : DLBCL
2021-05-05 : Hubschmann : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![MZL](https://github.com/morinlab/LLMPP/wiki/images/icons/MZL_tier1.png) |
1 |
high-confidence MZL gene |
![PMBL](https://github.com/morinlab/LLMPP/wiki/images/icons/PMBL_tier1.png) |
1 |
high-confidence PMBL/cHL/GZL gene[@wenigerMutationsTumorSuppressor2006a] |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
aSHM target and high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011; @lohrDiscoveryPrioritizationSomatic2012a; @zhangGeneticHeterogeneityDiffuse2013; @morinMutationalStructuralAnalysis2013] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier1.png) |
1 |
aSHM target and high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
15.30 |
DLBCL |
Schmitz cohort |
12.77 |
DLBCL |
Reddy cohort |
10.41 |
DLBCL |
Chapuy cohort |
4.70 |
FL |
GAMBL genomes |
9.70 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
Yes |
No |
4.476 |
0.000 |
DLBCL |
Yes |
Yes |
5.023 |
17.509 |
FL |
Yes |
Yes |
21.460 |
123.344 |
aSHM regions
chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
chr16 |
11347512 |
11350007 |
intron-1 |
enhancer |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/SOCS1_NM_003745.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/SOCS1.svg)
SOCS1 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/SOCS1_by_pathology.svg)
References