SOCS1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @lohrDiscoveryPrioritizationSomatic2012, @wenigerMutationsTumorSuppressor2006, @morinFrequentMutationHistonemodifying2011, @morinMutationalStructuralAnalysis2013, @zhangGeneticHeterogeneityDiffuse2013,
Experimental Evidence
Driver mutations affecting this gene in FL/DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@melznerBiallelicMutationSOCS12005]
Relevance tier by entity
include:tables/table1_SOCS1.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
FL
Mutation pattern and selective pressure estimates
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr16 | 11347512 | 11350007 | intron-1 | enhancer |
include:tables/browser_SOCS1.md
Expression
include:tables/mermaid_SOCS1.md