bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.1,2 Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
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timeline
title Publication timing
2017-01-26 : Krysiak : FL
2018-05-01 : Chapuy : DLBCL
2021-04-01 : Sarkozy : PMBL
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Entity
Tier
Description
1
high-confidence PMBL/cHL/GZL gene[@sarkozyMutationalLandscapeGray2021a]
1
high-confidence DLBCL gene [@chapuyMolecularSubtypesDiffuse2018b]
1
high-confidence FL gene [@krysiakRecurrentSomaticMutations2017b]
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity
source
frequency (%)
BL
GAMBL genomes+capture
4.62
BL
Thomas cohort
5.50
BL
Panea cohort
4.00
DLBCL
GAMBL genomes
8.41
DLBCL
Schmitz cohort
8.51
DLBCL
Reddy cohort
7.31
DLBCL
Chapuy cohort
9.83
FL
GAMBL genomes
5.54
Mutation pattern and selective pressure estimates
Entity
aSHM
Significant selection
dN/dS (missense)
dN/dS (nonsense)
BL
No
Yes
6.345
34.135
DLBCL
No
Yes
5.595
0.000
FL
No
No
19.175
0.000
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38