KLF2 (Kruppel-like factor 2) is a transcription factor involved in the regulation of various cellular processes, including apoptosis, proliferation, and differentiation. Mutations in KLF2 have been identified in various B-cell lymphomas including DLBCL.¹ KLF2 mutations are among the most common mutations in splenic marginal zone lymphoma (SMZL).² KLF2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. These mutations are associated with the BN2 genetic subgroup of DLBCL.³ KLF2 mutations have been shown to impair the ability of KLF2 to suppress NF-κB activation by TLR, BCR, BAFFR, and TNFR signaling, thereby promoting lymphomagenesis. This implicates KLF2 as a tumor suppressor in B-cell lymphomas.² Contradictory to this, the mutation pattern in DLBCL implies selective pressure to retain a full-length protein.

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timeline
    title Publication timing
      2011-07-31 : Pasqualucci : DLBCL
      2017-07-27 : Jallades : MZL
      2019-08-20 : Desch : PMBL

Entity	Tier	Description
	1	high-confidence MZL gene[@jalladesExomeSequencingIdentifies2017]
	2	relevance in PMBL/cHL/GZL not firmly established[@deschGenotypingCirculatingTumor2020]
	1-a	aSHM target and high-confidence DLBCL gene[@pasqualucciAnalysisCodingGenome2011]
	1-a	aSHM target and high-confidence FL gene

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