HIST1H1C - morinlab/LLMPP GitHub Wiki

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @paneaWholeGenomeLandscape2019, @crouchMolecularSubclustersFollicular2022, @morinFrequentMutationHistonemodifying2011,

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Overview

This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinFrequentMutationHistonemodifying2011; @crouchMolecularSubclustersFollicular2022] Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.

Relevance tier by entity

include:tables/table1_HIST1H1C.md

Warnings

<<Warn("The variants reported in BL in this gene failed QC")>>

See below or the study page for more information

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_HIST1H1C.md

BL

include:tables/BL_HIST1H1C.md

FL

include:tables/FL_HIST1H1C.md

Mutation pattern and selective pressure estimates

include:tables/dnds_HIST1H1C.md

include:tables/browser_HIST1H1C.md

include:tables/mermaid_HIST1H1C.md

References