STAT3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
STAT3
History
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timeline
title Publication timing
2011-07-27 : Morin : DLBCL
2012-03-06 : Lohr : DLBCL
2014-07-01 : Ohgami : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
2021-05-05 : Hubschmann : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene[@ohgamiSTAT3MutationsAre2014] |
 |
1 | high-confidence DLBCL gene [@lohrDiscoveryPrioritizationSomatic2012a; @morinFrequentMutationHistonemodifying2011; @reddyGeneticFunctionalDrivers2017] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 7.07 |
| DLBCL | Schmitz cohort | 9.36 |
| DLBCL | Reddy cohort | 3.60 |
| DLBCL | Chapuy cohort | 7.26 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | Yes | 27.471 | 12.427 |
| FL | No | No | 34.737 | 0.000 |
STAT3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr17 | 40475330 | C>T | D566N |
| chr17 | 40475325 | A>T | N567K |
| chr17 | 40475318 | C>T | D570N |
| chr17 | 40475317 | T>C | D570G |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
STAT3 Expression
