STAT3 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @ohgamiSTAT3MutationsAre2014, @morinFrequentMutationHistonemodifying2011, @lohrDiscoveryPrioritizationSomatic2012, @reddyGeneticFunctionalDrivers2017,
Experimental Evidence
Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a gain of function (GOF).[@huNovelMissenseM206K2013]
Relevance tier by entity
include:tables/table1_STAT3.md
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
Mutation pattern and selective pressure estimates
STAT3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr17 | 40475330 | C>T | D566N |
| chr17 | 40475325 | A>T | N567K |
| chr17 | 40475318 | C>T | D570N |
| chr17 | 40475317 | T>C | D570G |
include:tables/browser_STAT3.md
Expression
include:tables/mermaid_STAT3.md