SIN3A - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
SIN3A
History
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timeline
title Publication timing
2012-08-27 : Rossi : MZL
2018-05-01 : Chapuy : DLBCL
2018-10-01 : Arthur : DLBCL
2019-03-21 : Grande : BL
2021-05-05 : Hubschmann : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence BL gene [@grandeGenomewideDiscoverySomatic2019] |
 |
1 | high-confidence MZL gene [@rossiCodingGenomeSplenic2012c] |
 |
1 | high-confidence DLBCL gene[@chapuyMolecularSubtypesDiffuse2018b; @arthurGenomewideDiscoverySomatic2018] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 11.09 |
| BL | Thomas cohort | 10.60 |
| BL | Panea cohort | 14.90 |
| DLBCL | GAMBL genomes | 3.06 |
| DLBCL | Schmitz cohort | 2.77 |
| DLBCL | Reddy cohort | 3.00 |
| DLBCL | Chapuy cohort | 3.85 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 3.871 | 55.210 |
| DLBCL | No | No | 2.483 | 15.818 |
| FL | No | No | 0.000 | 20.676 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
SIN3A Expression
