SGK1 - morinlab/LLMPP GitHub Wiki

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @zhangGeneticHeterogeneityDiffuse2013, @morinMutationalStructuralAnalysis2013, @morinFrequentMutationHistonemodifying2011, @dunsCharacterizationDLBCLPMBL2021,

TOC

Experimental Evidence

Driver mutations affecting this gene in FL/DLBCL have been experimentally demonstrated to cause a gain of function (GOF).[@gaoSGK1MutationsDLBCL2021]

Relevance tier by entity

include:tables/table1_SGK1.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_SGK1.md

FL

include:tables/FL_SGK1.md

Mutation pattern and selective pressure estimates

include:tables/dnds_SGK1.md

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr6	134487960	134499859	TSS-1	active_promoter

Expression

include:tables/browser_SGK1.md

include:tables/mermaid_SGK1.md

References