SGK1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
SGK1
History
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timeline
title Publication timing
2011-07-27 : Morin : FL
2011-07-27 : Morin : DLBCL
2013-01-01 : Zhang : DLBCL
2013-08-15 : Morin : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
2018-10-01 : Arthur : DLBCL
2021-05-05 : Hubschmann : DLBCL
2021-07-15 : Duns : PMBL
Relevance tier by entity
Entity |
Tier |
Description |
![PMBL](https://github.com/morinlab/LLMPP/wiki/images/icons/PMBL_tier1.png) |
1 |
high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021b] |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
aSHM target and high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier1.png) |
1 |
aSHM target and high-confidence FL gene [@morinFrequentMutationHistonemodifying2011; @zhangGeneticHeterogeneityDiffuse2013; @morinMutationalStructuralAnalysis2013] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
11.09 |
DLBCL |
Schmitz cohort |
10.64 |
DLBCL |
Reddy cohort |
11.21 |
DLBCL |
Chapuy cohort |
12.82 |
FL |
GAMBL genomes |
6.00 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
Yes |
No |
5.451 |
7.487 |
DLBCL |
Yes |
Yes |
6.056 |
13.755 |
FL |
Yes |
Yes |
23.198 |
134.356 |
aSHM regions
chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
chr6 |
134487960 |
134499859 |
TSS-1 |
active_promoter |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/SGK1_NM_005627.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/SGK1.svg)
References
SGK1 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/SGK1_by_pathology.svg)