SGK1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
SGK1
History
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timeline
title Publication timing
2011-07-27 : Morin : FL
2011-07-27 : Morin : DLBCL
2013-01-01 : Zhang : DLBCL
2013-08-15 : Morin : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
2018-10-01 : Arthur : DLBCL
2021-05-05 : Hubschmann : DLBCL
2021-07-15 : Duns : PMBL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021b] |
 |
1 | aSHM target and high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011] |
 |
1 | aSHM target and high-confidence FL gene [@morinFrequentMutationHistonemodifying2011; @zhangGeneticHeterogeneityDiffuse2013; @morinMutationalStructuralAnalysis2013] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 11.09 |
| DLBCL | Schmitz cohort | 10.64 |
| DLBCL | Reddy cohort | 11.21 |
| DLBCL | Chapuy cohort | 12.82 |
| FL | GAMBL genomes | 6.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 5.451 | 7.487 |
| DLBCL | Yes | Yes | 6.056 | 13.755 |
| FL | Yes | Yes | 23.198 | 134.356 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr6 | 134487960 | 134499859 | TSS-1 | active_promoter |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
References
SGK1 Expression
