MZL_genes - morinlab/LLMPP GitHub Wiki
title: 'MZL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
Origins of MZL genes
Tier 1, high-confidence MZL genes
42 total
Gene | Summary | First MZL study | Other entities | QC result |
---|---|---|---|---|
ACTB | Tier 1 GE, aSHM | [@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @wienandGenomicAnalysesFlowsorted2019] | ||
ARID1A | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@barisicARID1AOrchestratesSWI2024] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @loveGeneticLandscapeMutations2012; @wienandGenomicAnalysesFlowsorted2019; @zhangGeneticHeterogeneityDiffuse2013] | |
ATM | Tier 1 GE[@braggioGenomicAnalysisMarginal2012], FE[@camachoATMGeneInactivation2002] | Braggio et al | [@beaLandscapeSomaticMutations2013; @reddyGeneticFunctionalDrivers2017] | |
BCL10 | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@xiaBCL10MutationsDefine2022] | Spina et al | [@morinFrequentMutationHistonemodifying2011; @russler-germainMutationsAssociatedProgression2023] | |
BCL7A | Tier 1 GE, FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM | [@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015] | ||
BIRC3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011], aSHM | Rossi et al | [@arthurGenomewideDiscoverySomatic2018; @beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021] | |
BRAF | Tier 1 GE, FE[@wanMechanismActivationRAFERK2004] | [@loveGeneticLandscapeMutations2012; @tiacciBRAFMutationsHairycell2011] | ||
BTG1 | Tier 1 GE, FE[@almasmoumFrequentLossBTG12021], aSHM | [@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021] | ||
CARD11 | Tier 1 GE[@yanBCRTLRSignaling2012], FE[@lenzOncogenicCARD11Mutations2008] | Yan et al | [@lenzOncogenicCARD11Mutations2008; @morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016] | |
CCND3 | Tier 1 GE[@jalladesExomeSequencingIdentifies2017], FE[@schmitzBurkittLymphomaPathogenesis2012] | Jallades et al | [@deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @richterRecurrentMutationID32012] | |
CXCR4 | Tier 1 GE, FE[@zmajkovicovaGenotypephenotypeCorrelationsWHIM2022], aSHM | [@khodabakhshiRecurrentTargetsAberrant2012; @krysiakRecurrentSomaticMutations2017; @paneaWholeGenomeLandscape2019] | ||
DTX1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], aSHM | Rossi et al | [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @zhangGeneticHeterogeneityDiffuse2013] | |
EP300 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] | Rossi et al | [@pasqualucciInactivatingMutationsAcetyltransferase2011] | |
EZH2 | Tier 1 GE, FE[@sneeringerCoordinatedActivitiesWildtype2010] | [@loveGeneticLandscapeMutations2012; @morinSomaticMutationsAltering2010; @mottokIntegrativeGenomicAnalysis2019] | ||
FAS | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@wangFasFADDDeathDomain2010] | Spina et al | [@morinFrequentMutationHistonemodifying2011; @schollMutationsRegionFAS2007] | |
FAT1 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
FOXO1 | Tier 1 GE, FE[@trinhAnalysisFOXO1Mutations] | [@dunsCharacterizationDLBCLPMBL2021; @morinFrequentMutationHistonemodifying2011; @schmitzBurkittLymphomaPathogenesis2012] | ||
H1-4 | Tier 1 GE | |||
H1-5 | Tier 1 GE | |||
ID3 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@richterRecurrentMutationID32012; @schmitzGeneticsPathogenesisDiffuse2018] | |
KLF2 | Tier 1 GE[@jalladesExomeSequencingIdentifies2017], aSHM | Jallades et al | [@deschGenotypingCirculatingTumor2020; @drevalGeneticSubdivisionsFollicular2023; @pasqualucciAnalysisCodingGenome2011] | |
KLHL6 | Tier 1 GE[@ganapathiGeneticLandscapeDural2016], FE[@choiLossKLHL6Promotes2018], aSHM | Ganapathi et al | [@morinFrequentMutationHistonemodifying2011] | |
KMT2D | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@zhangDisruptionKMT2DPerturbs2015] | Rossi et al | [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011] | |
MAP3K14 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@ottoGeneticLesionsTRAF32012] | |
MPEG1 | Tier 1 GE | [@morinMutationalStructuralAnalysis2013] | ||
MYD88 | Tier 1 GE[@yanBCRTLRSignaling2012], FE[@ngoOncogenicallyActiveMYD882011] | Yan et al | [@drevalGeneticSubdivisionsFollicular2023; @ngoOncogenicallyActiveMYD882011] | |
NCOR2 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@sarkozyMutationalLandscapeGray2021; @schmitzBurkittLymphomaPathogenesis2012] | |
NOL9 | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@schmitzGeneticsPathogenesisDiffuse2018] | |
NOTCH1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@ryanCellRegulomeLinks2017] | Rossi et al | [@beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012; @pasqualucciAnalysisCodingGenome2011] | |
NOTCH2 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@leeGainoffunctionMutationsCopy2009] | Rossi et al | [@beaLandscapeSomaticMutations2013; @zhangGeneticHeterogeneityDiffuse2013] | |
PCLO | Tier 1 GE | [@lohrDiscoveryPrioritizationSomatic2012] | ||
POU2AF1 | Tier 1 GE, FE[@gonzalez-rinconUnravelingTransformationFollicular2019], aSHM | [@chapuyMolecularSubtypesDiffuse2018; @krysiakRecurrentSomaticMutations2017] | ||
PTPRD | Tier 1 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@drevalGeneticSubdivisionsFollicular2023] | |
SIN3A | Tier 1 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@chapuyMolecularSubtypesDiffuse2018; @grandeGenomewideDiscoverySomatic2019] | |
SOCS1 | Tier 1 GE, FE[@melznerBiallelicMutationSOCS12005], aSHM | [@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006] | ||
SPEN | Tier 1 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@albuquerqueEnhancingKnowledgeDiscovery2017; @sarkozyMutationalLandscapeGray2021] | |
STAT6 | Tier 1 GE, FE[@mentzPARP14NovelTarget2022] | [@ritzRecurrentMutationsSTAT62009; @yildizActivatingSTAT6Mutations2015] | ||
TBL1XR1 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@venturuttiTBL1XR1MutationsDrive2020] | Rossi et al | [@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012] | |
TNFAIP3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011], FE[@compagnoMutationsMultipleGenes2009] | Rossi et al | [@compagnoMutationsMultipleGenes2009; @drevalGeneticSubdivisionsFollicular2023; @schmitzTNFAIP3A20Tumor2009] | |
TNFRSF14 | Tier 1 GE[@spinaGeneticsNodalMarginal2016], FE[@] | Spina et al | [@cheungAcquiredTNFRSF14Mutations2010; @morinFrequentMutationHistonemodifying2011] | |
TP53 | Tier 1 GE[@rossiCodingGenomeSplenic2012], FE[@katoUnderstandingFunctionstructureFunctionmutation2003] | Rossi et al | [@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018; @wildaInactivationARFMDM2p53Pathway2004] | |
TRAF3 | Tier 1 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@ottoGeneticLesionsTRAF32012; @pasqualucciAnalysisCodingGenome2011] |
Tier 2, low-confidence MZL genes
74 total
Gene | Summary | First MZL study | Other entities | QC result |
---|---|---|---|---|
ABCA13 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@sarkozyMutationalLandscapeGray2021] | |
ACTG1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016], aSHM | Spina et al | [@deschGenotypingCirculatingTumor2020; @fanComprehensiveCharacterizationDriver2020; @hubschmannMutationalMechanismsShaping2021] | |
ADD2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
AMN | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
AMOTL1 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
AOC2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
ARHGAP20 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
ARHGEF15 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
ARHGEF17 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
BCOR | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@nadeuGenomicEpigenomicInsights2020] | |
C6orf103 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
CBFA2T3 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
CD79A | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@burkhardtClinicalRelevanceMolecular2022] | |
CD9B | Tier 2 GE[@vandenbrandRecurrentMutationsGenes2017] | Vandenbrand et al | ||
CDC42BPB | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@hubschmannMutationalMechanismsShaping2021] | |
CDKN2A | Tier 2 GE[@spinaGeneticsNodalMarginal2016], FE[@kannengiesserFunctionalStructuralGenetic2009] | Spina et al | [@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013] | |
CLGN | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
CNBP | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
CNKSR2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
CREBBP | Tier 2 GE[@parryWholeExomeSequencing2013], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011] | Parry et al | [@dunsCharacterizationDLBCLPMBL2021; @loveGeneticLandscapeMutations2012; @pasqualucciInactivatingMutationsAcetyltransferase2011] | |
DNAH5 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@morinMutationalStructuralAnalysis2013] | |
DNAH7 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
DNAI1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
DOCK6 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
DSP | Tier 2 GE | [@zhangGeneticHeterogeneityDiffuse2013] | ||
DTNB | Tier 2 GE | |||
DTX3L | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
EGR1 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @reichelFlowSortingExome2015] | |
EGR2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
EZH1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
FAT4 | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | [@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014] | |
FBXO11 | Tier 2 GE[@parryWholeExomeSequencing2013], FE[@duanFBXO11TargetsBCL62011] | Parry et al | [@arthurGenomewideDiscoverySomatic2018; @richterRecurrentMutationID32012] | |
GPR98 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
GPS2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
HIST1H1D | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], aSHM | Jallades et al | [@krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013] | |
HIST1H2AD | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
HIST1H2AG | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019] | |
HIST1H2BK | Tier 2 GE[@rossiCodingGenomeSplenic2012], aSHM | Rossi et al | [@paneaWholeGenomeLandscape2019; @zhangGeneticHeterogeneityDiffuse2013] | |
HIST4H4 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
HRAS | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@reddyGeneticFunctionalDrivers2017] | |
IKBKB | Tier 2 GE[@rossiAlterationBIRC3Multiple2011] | Rossi et al | [@reddyGeneticFunctionalDrivers2017; @wienandGenomicAnalysesFlowsorted2019] | |
KAT6A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
KDM6A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
KIF26A | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
LRP1B | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
MCRS1 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
MGA | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], FE[@depaoliMGASuppressorMYC2013] | Jallades et al | [@reddyGeneticFunctionalDrivers2017] | |
MSL2 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
MYC | Tier 2 GE[@jalladesExomeSequencingIdentifies2017], FE[@freieGermlinePointMutation2024], aSHM | Jallades et al | [@dunsCharacterizationDLBCLPMBL2021; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001] | |
MYLK | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
NCOA6 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
NRAS | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
PACRG | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
PARK2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
PLA2G4D | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
PLXNB3 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@zhangGenomicLandscapeMantle2014] | |
RAF1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@fanComprehensiveCharacterizationDriver2020] | |
RAPGEF2 | Tier 2 GE | [@zhangGeneticHeterogeneityDiffuse2013] | ||
RCOR1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
RFTN1 | Tier 2 GE, aSHM | [@arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021] | ||
ROCK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
RPL1L | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
SAMD5 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
SCG3 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
STXBP5 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
SWAP70 | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | ||
TAF1 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | [@morinMutationalStructuralAnalysis2013] | |
TBK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | ||
TCTN2 | Tier 2 GE[@spinaGeneticsNodalMarginal2016] | Spina et al | ||
TNIP2 | Tier 2 GE[@vandenbrandRecurrentMutationsGenes2017] | Vandenbrand et al | ||
TRRAP | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@zhangGeneticHeterogeneityDiffuse2013] | |
USH2A | Tier 2 GE[@parryWholeExomeSequencing2013] | Parry et al | ||
WAC | Tier 2 GE[@rossiCodingGenomeSplenic2012] | Rossi et al | [@reddyGeneticFunctionalDrivers2017] | |
WNK1 | Tier 2 GE[@jalladesExomeSequencingIdentifies2017] | Jallades et al | [@hubschmannMutationalMechanismsShaping2021; @thomasGeneticSubgroupsInform2023] |
Tier 3, retired MZL genes
0 total
Gene | Summary | First MZL study | Other entities | QC result |
---|