bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
BCOR acts as a co-repressor of BCL6, and mutations in BCOR could impair its binding affinity to BCL6 and other partners. Overall, protein-altering mutations in BCOR seem to be rare in DLBCL and MCL.1,2 One study reported a much higher prevalence of a hot spot mutation in BCOR but this result has not been reproduced.1
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
title Publication timing
2017-07-27 : Jallades : MZL
2020-09-17 : Nadeu : MCL
Loading
Entity
Tier
Description
2
relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]
2
low-confidence DLBCL gene
1
high-confidence MCL gene [@nadeuGenomicEpigenomicInsights2020b]
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity
source
frequency (%)
DLBCL
GAMBL genomes
3.82
DLBCL
Schmitz cohort
7.66
DLBCL
Reddy cohort
2.50
DLBCL
Chapuy cohort
2.56
MCL
GAMBL genomes
3.79
Mutation pattern and selective pressure estimates
Entity
aSHM
Significant selection
dN/dS (missense)
dN/dS (nonsense)
BL
No
No
1.341
0
DLBCL
No
No
2.471
0
FL
No
No
1.743
0
Chromosome
Coordinate (hg19)
ref>alt
HGVSp
chrX
39921444
T>C
N1459S
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38