MYD88 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
MYD88
History
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timeline
title Publication timing
2011-02-03 : Ngo : DLBCL
2012-04-01 : Yan : MZL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene[@yanBCRTLRSignaling2012a] |
 |
1 | high-confidence DLBCL gene [@ngoOncogenicallyActiveMYD882011a] |
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 0.46 |
| BL | Thomas cohort | 0.40 |
| BL | Panea cohort | 1.00 |
| DLBCL | GAMBL genomes | 13.38 |
| DLBCL | Schmitz cohort | 26.38 |
| DLBCL | Reddy cohort | 15.12 |
| DLBCL | Chapuy cohort | 21.37 |
| FL | GAMBL genomes | 1.85 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.809 | 0 |
| DLBCL | No | Yes | 56.390 | 0 |
| FL | No | No | 17.159 | 0 |
MYD88 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr3 | 38182641 | T>C | L265P |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
MYD88 Expression
