MPEG1 - morinlab/LLMPP GitHub Wiki
Mutations in MPEG1 have been described in DLBCL1 with the overall rate of mutations somewhat variable across studies. MPEG1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. Coding and non-coding MPEG1 mutations are a feature of the MCD genetic subgroup of DLBCL.
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timeline
title Publication timing
2013-08-15 : Morin : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-10-01 : Arthur : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene |
 |
1 | high-confidence DLBCL gene[@morinMutationalStructuralAnalysis2013; @schmitzGeneticsPathogenesisDiffuse2018a] |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 4.78 |
| DLBCL | Schmitz cohort | 9.15 |
| DLBCL | Reddy cohort | 5.81 |
| DLBCL | Chapuy cohort | 10.68 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.434 | 0.000 |
| DLBCL | No | No | 1.449 | 1.685 |
| FL | No | No | 4.371 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
