MGA - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @jalladesExomeSequencingIdentifies2017, @reddyGeneticFunctionalDrivers2017,
Overview
MGA acts as a transcriptional repressor and interacts with MYC, a well-known oncogene. Mutations in MGA have been described in DLBCL.[@jalladesExomeSequencingIdentifies2017] One study suggested MGA mutations were more common in DLBCLs in patients of African ancestry.[@reddyGeneticFunctionalDrivers2017] The mutation pattern in MGA is consistent with a role as a tumour suppressor gene.
Experimental Evidence
Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@depaoliMGASuppressorMYC2013]
Relevance tier by entity
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
Mutation pattern and selective pressure estimates
Expression
