MGA - morinlab/LLMPP GitHub Wiki
MGA acts as a transcriptional repressor and interacts with MYC, a well-known oncogene. Mutations in MGA have been described in DLBCL.1 One study suggested MGA mutations were more common in DLBCLs in patients of African ancestry.2 The mutation pattern in MGA is consistent with a role as a tumour suppressor gene.
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timeline
title Publication timing
2017-07-27 : Jallades : MZL
2017-10-10 : Reddy : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017] |
 |
1 | high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017] |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 4.02 |
| DLBCL | Schmitz cohort | 7.23 |
| DLBCL | Reddy cohort | 4.70 |
| DLBCL | Chapuy cohort | 3.42 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| DLBCL | No | No | 1.432 | 12.504 |
| BL | No | No | 2.443 | 3.733 |
| FL | No | No | 0.000 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
