CD79A - morinlab/LLMPP GitHub Wiki
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CD79A
History
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timeline
title Publication timing
2012-08-27 : Rossi : MZL
2022-07-06 : Burkhardt : BL
Relevance tier by entity
Entity |
Tier |
Description |
|
2 |
relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012c] |
|
2 |
relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022b] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
BL |
GAMBL genomes+capture |
0.23 |
BL |
Thomas cohort |
NA |
BL |
Panea cohort |
NA |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.000 |
0.000 |
DLBCL |
No |
No |
1.810 |
16.146 |
FL |
No |
No |
3.676 |
33.801 |
CD79A Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr19 |
42384963 |
T>A |
Y199* |
chr19 |
42384963 |
T>G |
Y199* |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
CD79A Expression
References
- Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537–1551. PMCID: PMC3428941
- Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584