---

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

TNFRSF14

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2010-11-15 : Cheung : FL
      2011-07-27 : Morin : DLBCL
2012-03-06 : Lohr : DLBCL
2013-01-01 : Zhang : DLBCL
2013-08-15 : Morin : DLBCL
      2016-09-08 : Spina : MZL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence MZL gene[@spinaGeneticsNodalMarginal2016b]
	1	high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]
	1	high-confidence FL gene[@cheungAcquiredTNFRSF14Mutations2010a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	14.34
DLBCL	Schmitz cohort	16.81
DLBCL	Reddy cohort	9.71
DLBCL	Chapuy cohort	12.82
FL	GAMBL genomes	40.42

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	1.388	34.410
DLBCL	No	Yes	32.541	207.456
FL	No	Yes	96.380	1034.281

TNFRSF14 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr1	2488104	A>G	M1?
chr1	2488105	T>C	M1?
chr1	2488105	T>G	M1?
chr1	2488106	G>A	M1?
chr1	2488107	G>T	E2*
chr1	2488123	G>A	W7*
chr1	2488124	G>A	W7*
chr1	2488132	C>A	P10H
chr1	2488138	G>A	W12*
chr1	2488139	G>A	W12*
chr1	2488152	A>T	K17*
chr1	2488156	C>A	T18N

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TNFRSF14 Expression

References