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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true nocite: | @spinaGeneticsNodalMarginal2016, @cheungAcquiredTNFRSF14Mutations2010a -->, @morinFrequentMutationHistonemodifying2011, @spinaGeneticsNodalMarginal2016b -->, @cheungAcquiredTNFRSF14Mutations2010,

TOC

Experimental Evidence

Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).

Relevance tier by entity

include:tables/table1_TNFRSF14.md

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

include:tables/DLBCL_TNFRSF14.md

FL

include:tables/FL_TNFRSF14.md

Mutation pattern and selective pressure estimates

include:tables/dnds_TNFRSF14.md

TNFRSF14 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr1	2488104	A>G	M1?
chr1	2488105	T>C	M1?
chr1	2488105	T>G	M1?
chr1	2488106	G>A	M1?
chr1	2488107	G>T	E2*
chr1	2488123	G>A	W7*
chr1	2488124	G>A	W7*
chr1	2488132	C>A	P10H
chr1	2488138	G>A	W12*
chr1	2488139	G>A	W12*
chr1	2488152	A>T	K17*
chr1	2488156	C>A	T18N

include:tables/browser_TNFRSF14.md

Expression

include:tables/mermaid_TNFRSF14.md

References