TRRAP - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
TRRAP
History
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timeline
title Publication timing
2012-08-27 : Rossi : MZL
2013-01-01 : Zhang : DLBCL
2013-12-13 : Parry : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![MZL](https://github.com/morinlab/LLMPP/wiki/images/icons/MZL_tier2.png) |
2 |
relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012c] |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
3 |
Retired for DLBCL[@zhangGeneticHeterogeneityDiffuse2013] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
2.87 |
DLBCL |
Schmitz cohort |
8.94 |
DLBCL |
Reddy cohort |
3.50 |
DLBCL |
Chapuy cohort |
5.98 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.571 |
0 |
DLBCL |
No |
No |
1.296 |
0 |
FL |
No |
No |
2.757 |
0 |
TRRAP Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr7 |
98509802 |
C>T |
S722F |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/TRRAP_NM_003496.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/TRRAP.svg)
TRRAP Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/TRRAP_by_pathology.svg)
References