PC - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
PC
Due to minimal support in the original primary data, low expression in BL and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL. <<Warn("The variants reported in this gene in BL failed QC")>>
History
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timeline
title Publication timing
2012-12-01 : Love : BL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
3 | Retired, Failed QC[@loveGeneticLandscapeMutations2012] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 2.54 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.187 | 0.000 |
| DLBCL | No | No | 0.000 | 10.914 |
| FL | No | No | 0.000 | 27.654 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
PC Expression
Representative Mutations
Rating
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Rating
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