CCT6B - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
CCT6B
Overview
Due to minimal support in the original primary data and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL.
<<Warn("The variants reported in this gene failed QC")>>
History
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timeline
title Publication timing
2012-12-01 : Love : BL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
3 | Retired, Failed QC[@loveGeneticLandscapeMutations2012] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 1.15 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.893 | 0 |
| DLBCL | No | No | 0.000 | 0 |
| FL | No | No | 0.000 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
CCT6B Expression
Representative Mutation
Although well supported in the data, this mutation is clearly germline