---

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

ZNF608

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2013-08-15 : Morin : DLBCL
      2017-01-26 : Krysiak : FL
      2017-10-10 : Reddy : DLBCL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in FL not firmly established[@krysiakRecurrentSomaticMutations2017b]
	1	high-confidence DLBCL gene[@morinMutationalStructuralAnalysis2013; @reddyGeneticFunctionalDrivers2017]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	6.12
DLBCL	Schmitz cohort	9.36
DLBCL	Reddy cohort	8.11
DLBCL	Chapuy cohort	7.69

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.986	0.000
DLBCL	No	No	1.714	3.638
FL	No	No	1.867	4.218

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

ZNF608 Expression

References