ZC3H12A - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
ZC3H12A
History
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timeline
title Publication timing
2018-05-01 : Chapuy : DLBCL
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![MCL](https://github.com/morinlab/LLMPP/wiki/images/icons/MCL_tier2.png) |
2 |
relevance in MCL not firmly established |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier1.png) |
1 |
high-confidence DLBCL gene [@chapuyMolecularSubtypesDiffuse2018b; @arthurGenomewideDiscoverySomatic2018] |
![FL](https://github.com/morinlab/LLMPP/wiki/images/icons/FL_tier2.png) |
2 |
relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
2.68 |
DLBCL |
Schmitz cohort |
5.96 |
DLBCL |
Reddy cohort |
3.10 |
DLBCL |
Chapuy cohort |
4.70 |
FL |
GAMBL genomes |
0.46 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
0.000 |
0.000 |
DLBCL |
No |
No |
2.488 |
18.944 |
FL |
No |
No |
0.000 |
0.000 |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/ZC3H12A_NM_025079.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/ZC3H12A.svg)
ZC3H12A Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/ZC3H12A_by_pathology.svg)
References