XBP1 - morinlab/LLMPP GitHub Wiki
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XBP1
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| DLBCL |
GAMBL genomes |
1.15 |
| DLBCL |
Schmitz cohort |
1.28 |
| DLBCL |
Reddy cohort |
1.60 |
| DLBCL |
Chapuy cohort |
NA |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
Yes |
No |
1.624 |
39.881 |
| DLBCL |
Yes |
No |
1.835 |
0.000 |
| FL |
Yes |
No |
2.607 |
0.000 |
aSHM regions
| chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
| chr22 |
29194943 |
29197461 |
TSS |
NA |
include:tables/browser_XBP1.md
Expression
References