TOX - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
TOX
History
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timeline
title Publication timing
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
2021-05-05 : Hubschmann : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
|
1 |
high-confidence DLBCL gene [@reddyGeneticFunctionalDrivers2017; @schmitzGeneticsPathogenesisDiffuse2018a; @chapuyMolecularSubtypesDiffuse2018b; @hubschmannMutationalMechanismsShaping2021b] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
4.21 |
DLBCL |
Schmitz cohort |
5.53 |
DLBCL |
Reddy cohort |
4.00 |
DLBCL |
Chapuy cohort |
5.13 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
No |
No |
1.503 |
17.955 |
DLBCL |
No |
No |
3.481 |
12.292 |
FL |
No |
No |
1.975 |
21.081 |
TOX Hotspots
Chromosome |
Coordinate (hg19) |
ref>alt |
HGVSp |
chr8 |
60031445 |
C>G |
K34N |
chr8 |
60031445 |
C>T |
K34= |
chr8 |
60031446 |
T>G |
K34T |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TOX Expression
References