TLR2 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
TLR2
History
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timeline
title Publication timing
2013-11-05 : Bea : MCL
2018-05-01 : Chapuy : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in DLBCL not firmly established[@chapuyMolecularSubtypesDiffuse2018b] |
 |
1 | high-confidence MCL gene [@beaLandscapeSomaticMutations2013] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.87 |
| DLBCL | Schmitz cohort | 2.77 |
| DLBCL | Reddy cohort | 1.50 |
| DLBCL | Chapuy cohort | 2.99 |
| MCL | GAMBL genomes | 0.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.141 | 0 |
| DLBCL | No | No | 3.705 | 0 |
| FL | No | No | 0.000 | 0 |
TLR2 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr4 | 154625039 | A>T | D327V |
| chr4 | 154625042 | T>G | L328R |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TLR2 Expression
All Mutations
DLBCL-RICOVER_1269-Tumor DLBCL-RICOVER_174-Tumor