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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

TCL1A

History

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timeline
    title Publication timing
      2019-03-21 : Grande : BL

Relevance tier by entity

Entity	Tier	Description
	1-a	aSHM target and high-confidence BL gene [@grandeGenomewideDiscoverySomatic2019]
	1-a	aSHM target and high-confidence DLBCL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	4.16
BL	Thomas cohort	5.90
BL	Panea cohort	4.00
DLBCL	GAMBL genomes	2.10
DLBCL	Schmitz cohort	3.83
DLBCL	Reddy cohort	2.80
DLBCL	Chapuy cohort	2.99

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	Yes	13.813	49.800
DLBCL	Yes	Yes	25.501	112.487
FL	Yes	No	30.159	88.355

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr14	96179535	96180366	TSS	active_promoter

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TCL1A Expression

References