TBC1D4 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
TBC1D4
History
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timeline
title Publication timing
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
Entity |
Tier |
Description |
![DLBCL](https://github.com/morinlab/LLMPP/wiki/images/icons/DLBCL_tier2.png) |
2-a |
aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Entity |
source |
frequency (%) |
DLBCL |
GAMBL genomes |
2.29 |
DLBCL |
Schmitz cohort |
5.11 |
DLBCL |
Reddy cohort |
2.70 |
DLBCL |
Chapuy cohort |
5.56 |
Mutation pattern and selective pressure estimates
Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
BL |
Yes |
No |
0.792 |
0.000 |
DLBCL |
Yes |
No |
1.783 |
6.266 |
FL |
Yes |
No |
0.860 |
0.000 |
aSHM regions
chr_name |
hg19_start |
hg19_end |
region |
regulatory_comment |
chr13 |
75982519 |
75986015 |
intron |
NA |
View coding variants in ProteinPaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/TBC1D4_NM_014832.svg)
View all variants in GenomePaint hg19 or hg38
![](https://github.com/morinlab/LLMPP/wiki/images/proteinpaint/TBC1D4.svg)
TBC1D4 Expression
![](https://github.com/morinlab/LLMPP/wiki/images/gene_expression/TBC1D4_by_pathology.svg)
References