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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

RHOH

Relevance tier by entity

Entity	Tier	Description
	2-a	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@pasqualucciHypermutationMultipleProtooncogenes2001a]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	1.15
DLBCL	Schmitz cohort	0.43
DLBCL	Reddy cohort	0.10
DLBCL	Chapuy cohort	NA

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	0.000	0
DLBCL	Yes	No	4.612	0
FL	Yes	No	0.000	0

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr4	40193105	40204231	TSS	active_promoter

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

RHOH Expression

References