RB1 - morinlab/LLMPP GitHub Wiki
bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true
RB1
History
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timeline
title Publication timing
2013-08-15 : Morin : DLBCL
2014-05-08 : Zhang : MCL
2017-10-10 : Reddy : DLBCL
2018-10-01 : Arthur : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence DLBCL gene[@morinMutationalStructuralAnalysis2013; @reddyGeneticFunctionalDrivers2017; @arthurGenomewideDiscoverySomatic2018] |
 |
1 | high-confidence MCL gene [@zhangGenomicLandscapeMantle2014] |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 4.78 |
| DLBCL | Schmitz cohort | 3.19 |
| DLBCL | Reddy cohort | 1.60 |
| DLBCL | Chapuy cohort | 3.85 |
| MCL | GAMBL genomes | 0.47 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.029 | 6.855 |
| DLBCL | No | Yes | 0.933 | 17.514 |
| FL | No | No | 1.890 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
RB1 Expression
